Results 1 to 10 of about 75,767 (117)

EP3 is the only prostaglandin E receptor required for lipopolysaccharide-induced fever [PDF]

Brain, Behavior, & Immunity - Health
Fever induced by systemic inflammation is mediated by prostaglandin E2 (PGE2), but the identity of the prostaglandin E (EP) receptor subtype responsible for the febrile response remains debated.
Unn Kugelberg, Anna Erkstam, Kiseko Shionoya, Anders Blomqvist   +3 more
doaj   +2 more sources

Exercise, Prostaglandin E₂, and Cardiometabolic Health: From Molecular Signaling to Systemic Adaptation [PDF]

Cells
Exercise is a cost-effective cornerstone therapy available to all for the treatment of cardiometabolic disorders, yet the molecular mediators linking physical activity to systemic metabolic and cardiovascular adaptations remain incompletely defined ...
Joseph Mannozzi, Mike M. Ravn Pedersen, Shaheen Y. Bhat, Timothy D. Bryson   +3 more
doaj   +2 more sources

The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production [PDF]

Poultry Science
Oxidative stress and inflammation commonly occur in modern poultry farming, where they are closely linked mechanistically during the progression of disease and adaptation to stressors. This review synthesizes current evidence to outline cyclooxygenase-2 (
Xueqing Xiao, Wenrui Zhen, Dongying Bai, Bo Zheng, Yanli Wang, Xiqiang Ma, Xiaolin Xie, Yi Zhang, Fangshen Guo, Koichi Ito, Bingkun Zhang, Cai Zhang, Yanbo Ma   +12 more
doaj   +2 more sources

Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. [PDF]

PLoS ONE, 2011
Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis,
Josef Anrather, Eduardo F Gallo, Takayuki Kawano, Marcello Orio, Takato Abe, Camile Gooden, Ping Zhou, Costantino Iadecola   +7 more
doaj   +1 more source

Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

Nature Communications, 2023
Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However,
Xiuqing Lv, Kaixuan Gao, Jia Nie, Xin Zhang, Shuhao Zhang, Yinhang Ren, Xiaoou Sun, Qi Li, Jingrui Huang, Lijuan Liu, Xiaowen Zhang, Weishe Zhang, Xiangyu Liu   +12 more
doaj   +1 more source

Expression of Prostaglandin E Receptors in Acquired Middle Ear Cholesteatoma [PDF]

Clinical and Experimental Otorhinolaryngology, 2018
Objectives To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. Methods Specimens of human acquired cholesteatoma
Sujie Wang, Li Xie, Yanfei Zhang, Pengfei Xu, Aiguo Liu   +4 more
doaj   +1 more source

Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis

Translational Neurodegeneration, 2023
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cord is a focus ...
Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge   +5 more
doaj   +1 more source

Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure

Frontiers in Endocrinology, 2022
Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in sustaining volume and hemodynamics homeostasis.
Lu Wang, Lu Wang, Lu Wang, Yiqian Wu, Yiqian Wu, Yiqian Wu, Zhanjun Jia, Zhanjun Jia, Jing Yu, Jing Yu, Songming Huang, Songming Huang, Songming Huang   +12 more
doaj   +1 more source

Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E 2 and leukotriene B 4 signaling in apical periodontitis [PDF]

Journal of Applied Oral Science, 2020
Purpose To evaluate the kinetics of apical periodontitis development in vivo , induced either by contamination of the root canals by microorganisms from the oral cavity or by inoculation of bacterial lipopolysaccharide (LPS) and the regulation of major ...
Francisco Wanderley Garcia PAULA-SILVA, Fernanda Regina RIBEIRO-SANTOS, Igor Bassi Ferreira PETEAN, Maya Fernanda MANFRIN ARNEZ, Luciano Aparecido de ALMEIDA-JUNIOR, Fabrício Kitazono de CARVALHO, Léa Assed Bezerra da SILVA, Lúcia Helena FACCIOLI   +7 more
doaj   +1 more source

Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. [PDF]

PLoS ONE, 2014
The functional and molecular alterations of nerve growth factor (NGF) and Prostaglandin E2 (PGE2) and its receptors were studied in bladder and urine in streptozotocin (STZ)-induced diabetic rats.Diabetes mellitus was induced with a single dose of 45 mg ...
Jayabalan Nirmal, Pradeep Tyagi, Yao-Chi Chuang, Wei-Chia Lee, Naoki Yoshimura, Chao-Cheng Huang, Bharathi Rajaganapathy, Michael B Chancellor   +7 more
doaj   +1 more source