Results 41 to 50 of about 31,453,429 (295)

Prostaglandin E2-induced colonic secretion in patients with and without colorectal neoplasia

BMC Gastroenterology, 2010
Background The pathogenesis for colorectal cancer remains unresolved. A growing body of evidence suggests a direct correlation between cyclooxygenase enzyme expression, prostaglandin E2 metabolism and neoplastic development. Thus further understanding of
Poulsen Steen S, Osbak Philip S, Witte Anne-Barbara, Tilotta Maria C, Kaltoft Nicolai, Bindslev Niels, Hansen Mark B   +6 more
doaj   +1 more source

The role of prostaglandin and antioxidant availability in recovery from forearm ischemia-reperfusion injury in humans [PDF]

, 2014
This article is made available through the Brunel Open Access Publishing Fund. It is shared under the Creative Commons License Attribution-Noncommercial No Derivative 3.0 (CCBY NCND).
Carter, SE, Rakobowchuk, Mark, Rakobowchuk, M, Essex, Carter, Sophie E, Carter, Sophie E., Faulkner, A, Carter, S E, Brunel, Faulkner, Ashton, Carter, Sophie   +10 more
core   +1 more source

mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation

Cellular Physiology and Biochemistry, 2017
Background/Aims: We previously reported that indoxyl sulfate (IS) could cause mesangial cell (MC) proliferation via a cyclooxygenase (COX)-2-dependent mechanism.
Shuzhen Li, Zhenzhen Sun, Guixia Ding, Wei Gong, Jing Yu, Weiwei Xia, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source

Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34

Journal of Pharmacological Sciences, 2017
Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Although recent studies have shown that PGE2 induces cell differentiation in some neuronal cells such as mouse DRG neurons and sensory neuron-like ND7/
Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Kosuke Sugawa, Yoshihisa Ito, Kumiko Ishige   +5 more
doaj   +1 more source

Evaluation of Prostaglandin E2 and E-Series Prostaglandin Receptor in Patients with Interstitial Cystitis

Journal of Urology, 2015
We evaluated PGE2 and EP receptor in patients with interstitial cystitis.Enrolled in the study were 20 female patients with interstitial cystitis (11 with and 9 without Hunner lesions), 9 female controls with another urological disease who needed a cystoscopic procedure and 10 normal volunteers.
Wada, Naoki, Ameda, Kaname, Furuno, Tsuyoshi, Okada, Hiroki, Date, Ichiro, Kakizaki, Hidehiro   +5 more
openaire   +4 more sources

Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E₂ in rat microglial cultures

Journal of Neuroinflammation, 2005
Background Nicotinic acetylcholine (Ach) receptors are ligand-gated pentameric ion channels whose main function is to transmit signals for the neurotransmitter Ach in peripheral and central nervous system.
Minghetti Luisa, Carnevale Daniela, Ajmone-Cat Maria, De Simone Roberta   +3 more
doaj   +1 more source

Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions [PDF]

PeerJ, 2013
Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, has vasodilatory properties and is used widely in various clinical settings. In addition to acute vasodilatory properties, PGE1 may exert beneficial effects by altering protein expression of
Kengo Suzuki, Kenichiro Nishi, Satoshi Takabuchi, Shinichi Kai, Tomonori Matsuyama, Shin Kurosawa, Takehiko Adachi, Takayuki Maruyama, Kazuhiko Fukuda, Kiichi Hirota   +9 more
doaj   +2 more sources

Upregulation of Cyclooxygenase-2/Prostaglandin E (COX-2/PGE) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer

Breast Cancer: Basic and Clinical Research, 2016
Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2 ) are indicators of a poor prognosis in breast cancer. Using several independent publicly available breast cancer gene expression databases, we investigated other members of the PGE
Tyler J. Kochel, Olga G. Goloubeva, Amy M. Fulton   +2 more
doaj   +1 more source

Impaired Bone Resorption to Prostaglandin E2 in Prostaglandin E Receptor EP4-knockout Mice [PDF]

Journal of Biological Chemistry, 2000
Prostaglandin E(2) (PGE(2)) acts as a potent stimulator of bone resorption. In this study, we first clarified in normal ddy mice the involvement of protein kinase A and induction of matrix metalloproteinases (MMPs) in PGE(2)-induced bone resorption, and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype
C, Miyaura, M, Inada, T, Suzawa, Y, Sugimoto, F, Ushikubi, A, Ichikawa, S, Narumiya, T, Suda   +7 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source