Results 51 to 60 of about 31,453,429 (295)

Mechanisms involved in PGE₂-induced transactivation of the epidermal growth factor receptor in MH₁C₁ hepatocarcinoma cells

Journal of Experimental & Clinical Cancer Research, 2012
Background It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiology of hepatocarcinomas. Data also
Tveteraas Ingun, Müller Kristin, Aasrum Monica, Ødegård John, Dajani Olav, Guren Tormod, Sandnes Dagny, Christoffersen Thoralf   +7 more
doaj   +1 more source

The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E₂ in rat stomach [PDF]

Alimentary Pharmacology & Therapeutics, 2000
Summary Aim: To investigate the EP receptor subtype involved in the gastroprotective action of prostaglandin (PG) E2 using various EP receptor agonists in rats, and using knockout mice lacking EP1 or EP3 receptors. Methods: Male SD rats and C57BL/6 mice were used after an 18‐h fast.
H, Araki, H, Ukawa, Y, Sugawa, K, Yagi, K, Suzuki, K, Takeuchi   +5 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction [PDF]

, 2020
Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy.
Junyan Zhu, Viktoria von Schönfeldt, Lin, Peng, Jeschke, Udo, Ye, Yao, Zhu, Junyan, Yao Ye, Peng Lin, Udo Jeschke, von Schönfeldt, Viktoria   +9 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A maladaptive role for EP4 receptors in mouse mesangial cells. [PDF]

PLoS ONE, 2014
Roles of the prostaglandin E2 E-prostanoid 4 receptor (EP4) on extracellular matrix (ECM) accumulation induced by TGF-β1 in mouse glomerular mesangial cells (GMCs) remain unknown. Previously, we have identified that TGF-β1 stimulates the expression of FN
Guang-xia Yang, Yu-yin Xu, Ya-ping Fan, Jing Wang, Xiao-lan Chen, Yi-de Zhang, Jian-hua Wu   +6 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4

Frontiers in Immunology, 2021
Emerging evidence suggests a mechanistic role for myeloid-derived suppressor cells (MDSCs) in lung diseases like asthma. Previously, we showed that adoptive transfer of MDSCs dampens lung inflammation in murine models of asthma through cyclooxygenase-2 ...
Chiel van Geffen, Chiel van Geffen, Chiel van Geffen, Astrid Deißler, Sandra Beer-Hammer, Bernd Nürnberg, Rupert Handgretinger, Harald Renz, Harald Renz, Dominik Hartl, Dominik Hartl, Saeed Kolahian, Saeed Kolahian, Saeed Kolahian   +13 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue[S]

Journal of Lipid Research, 2015
Inflammation of adipose tissue induces metabolic derangements associated with obesity. Thus, determining ways to control or inhibit inflammation in adipose tissue is of clinical interest.
Eva H.C. Tang, Yin Cai, Chi Kin Wong, Viviane Z. Rocha, Galina K. Sukhova, Koichi Shimizu, Ge Xuan, Paul M. Vanhoutte, Peter Libby, Aimin Xu   +9 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source