Results 1 to 10 of about 89,482 (299)

Multifaceted roles of PGE2 in inflammation and cancer [PDF]

Seminars in Immunopathology, 2012
Prostaglandin E(2) (PGE(2)) is a bioactive lipid that elicits a wide range of biological effects associated with inflammation and cancer. PGE(2) exerts diverse effects on cell proliferation, apoptosis, angiogenesis, inflammation, and immune surveillance.
Daniel W Rosenberg, Masako Nakanishi
exaly   +3 more sources

Statin Gastroprotective Mechanisms Independent of Gastric Acid Suppression [PDF]

المجلة العراقية للصيدلة, 2023
Background: Statins have demonstrated various beneficial clinical outcomes, not only in patients with elevated cholesterol levels but also in those with normal levels, a collective phenomenon known as pleiotropic effects.
Dilgash Abdullah, Hani Almukhtar
doaj   +1 more source

Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus aureus and Trichomonas vaginalis [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Vaginal abscess in pregnant women caused by Staphylococcus aureus and Trichomonas vaginalis is one of the most important disease. This infection is still medically uncontrolled because of poor health awareness due to the absence of personal
Ahmed Abduljabbar Jaloob Aljanaby, Saleem Alhadraawy, Sukayna Mushattat   +2 more
doaj   +1 more source

Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells

OncoImmunology, 2021
The similarity of stromal-like Wilms tumor (str-WT) cells with mesenchymal stem cells (MSC), suggests their relevant role in the interplay with immune cells in the tumor microenvironment. We investigated the interaction between str-WT cells and NK cells.
Claudia Cantoni, Martina Serra, Erica Parisi, Bruno Azzarone, Angela Rita Sementa, Luigi Aurelio Nasto, Lorenzo Moretta, Giovanni Candiano, Cristina Bottino, Gian Marco Ghiggeri, Grazia Maria Spaggiari   +10 more
doaj   +1 more source

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

eLife, 2021
Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation.
Ada Weinstock, Karishma Rahman, Or Yaacov, Hitoo Nishi, Prashanthi Menon, Cyrus A Nikain, Michela L Garabedian, Stephanie Pena, Naveed Akbar, Brian E Sansbury, Sean P Heffron, Jianhua Liu, Gregory Marecki, Dawn Fernandez, Emily J Brown, Kelly V Ruggles, Stephen A Ramsey, Chiara Giannarelli, Matthew Spite, Robin P Choudhury, P'ng Loke, Edward A Fisher   +21 more
doaj   +1 more source

The association between repeated doses of vaginal PGE2 (Dinoprostone, Prostin®) and both maternal and neonatal outcomes among women in the north of Jordan

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: To evaluate the association between repeated doses of vaginal PGE2 and the maternal and neonatal outcomes for primigravid and multiparous women. Study design: A retrospective descriptive study was conducted at a teaching university hospital in
A.M. Sindiani, H.M. Rawashdeh, E.H. Alshdaifat, O.F. Altal, H. Yaseen, A.A. Alhowary   +5 more
doaj   +1 more source

Estradiol-17β, Prostaglandin E2 (PGE2), and the PGE2 Receptor Are Involved in PGE2 Positive Feedback Loop in the Porcine Endometrium [PDF]

Endocrinology, 2009
Before implantation, the porcine endometrium and trophoblast synthesize elevated amounts of luteoprotective prostaglandin estradiol-17beta (E(2)) (PGE(2)). We hypothesized that embryo signal, E(2), and PGE(2) modulate expression of key enzymes in PG synthesis: PG-endoperoxide synthase-2 (PTGS2), microsomal PGE synthase (mPGES-1), PGF synthase (PGFS ...
Agnieszka, Waclawik, Henry N, Jabbour, Agnieszka, Blitek, Adam J, Ziecik   +3 more
openaire   +2 more sources

Is There a Role for PGE2 in Urinary Concentration? [PDF]

Journal of the American Society of Nephrology, 2013
Prostanoids are prominent, yet complex, components in the maintenance of body water homeostasis. Recent functional and molecular studies have revealed that the local lipid mediator PGE2 is involved both in water excretion and absorption. The biologic actions of PGE2 are exerted through four different G-protein-coupled receptors; designated EP1-4, which
Olesen, Emma T B, Fenton, Robert A.; id_orcid 0000-0003-1623-199X   +1 more
openaire   +3 more sources

Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Breast cancer-related depression (BCRD) is strongly associated with BC and increases recurrence and mortality. This study investigated the role of kaempferol in the pathogenesis of BCRD and its underlying mechanism.
Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi   +6 more
doaj   +1 more source

Granulosa cell proliferation is inhibited by PGE2 in the primate ovulatory follicle

Animal Cells and Systems, 2020
Prostaglandin E2 (PGE2) is a key paracrine mediator of ovulation. Few specific PGE2-regulated gene products have been identified, so we hypothesized that PGE2 may regulate the expression and/or activity of a network of proteins to promote ovulation.
Patric S. Lundberg, Gil J. Moskowitz, Carmel Bellacose, Esra Demirel, Heidi A. Trau, Diane M. Duffy   +5 more
doaj   +1 more source