Results 41 to 50 of about 89,482 (299)

TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1. [PDF]

PLoS ONE, 2013
Transforming growth factor-ß1 (TGF-β1) is a multifunctional cytokine that is involved in various pathophysiological processes, including cancer progression and fibrotic disorders.
Erina Takai, Mitsutoshi Tsukimoto, Shuji Kojima   +2 more
doaj   +1 more source

Hambatan Prostaglandin pada Pemberian OAINS dan Non-OAINS Pasca Pemakaian Alat Ortodontik

Journal of Experimental Life Science, 2013
Alat ortodontik pada bidang kedokteran digunakan untuk merapikan gigi agar tersusun rapi dan berada pada lengkung rahang. Sehingga mengakibatkan tekanan yang akan merangsang dan menimbulkan reaksi inflamasi jaringan sekitar. Salah satu mediator inflamasi
Shanty Sintessa, H. M. Soemarko, Liliek Suprapti, Iwan Hernawan   +3 more
doaj   +1 more source

Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors

The Journal of Reproduction and Development, 2020
Recently, we established an in vitro model with immortalized dog uterine stromal (DUS) cells for investigations into canine-specific decidualization. Their capability to decidualize was assessed with cAMP and prostaglandin (PG) E2. Here, we show that the
Felix R. GRAUBNER, Miguel TAVARES PEREIRA, Alois BOOS, Mariusz P. KOWALEWSKI   +3 more
doaj   +1 more source

The sustained PGE2 release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model

Journal of Nanobiotechnology, 2022
Background The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration.
Haoyan Huang, Shang Chen, Hui Cheng, Jiasong Cao, Wei Du, Jun Zhang, Yuqiao Chang, Xiaohong Shen, Zhikun Guo, Zhibo Han, Guoqiang Hua, Zhong-Chao Han, Nadia Benkirane-Jessel, Ying Chang, Zongjin Li   +14 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells [PDF]

, 2016
The upregulation of PGE2 by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated to trigger a huge increase of PGE2 synthesis and were treated in the absence or presence of ...
Vasilakaki, Sofia, Magrioti, Victoria, Pastukhov, Oleksandr, Barbayianni, Efrosini, Kokotos, George, Huwiler, Andrea, Constantinou-Kokotou, Violetta   +6 more
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis

Open Medicine
This study aimed to investigate the changes of serum carbohydrate antigen 125 (CA125) and prostaglandin E2 (PGE2) in patients with adenomyosis before and after treatment with high-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing ...
Huang Yan, Zhou Yuzhen, Chen Huixian, Xu Yanyi   +3 more
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source