Results 31 to 40 of about 89,482 (299)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising ...
Tarek S. Ibrahim +6 more
doaj +1 more source
Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. [PDF]
, 2016 Endometriosis is characterized by the ectopic development of the endometrium which relies on angiogenesis. Although studies have identified the involvement of different matrix metalloproteinases (MMPs) in endometriosis, no study has yet investigated the ...
Amlan K Ray +9 more
core +1 more source
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Some species of Prunus L. are popularly used to treat gastric ulcers. However, the possible healing mechanisms of the anti-ulcer activity of P.
Nihal Cetin +9 more
doaj +1 more source
PGE2-mediated MMP-2 activity promotes angiogenesis in endometriosis.
, 2016 Endometriosis is an inflammatory, proliferative disease with increased PGE2 responses. The production of PGE2 from arachidonic acid (A.A.) is regulated by cycloxygenase-2 (COX-2).
Sayantan Jana (3190551) +4 more
core +1 more source
OncoImmunology, 2017 Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived suppressor cells (MDSC), and regulatory T cells (Tregs), represents a promising strategy for ...
Diana I. Albu +17 more
doaj +1 more source
Prostaglandin E2 (PGE2) exerts biphasic effects on human tendon stem cells. [PDF]
PLoS ONE, 2014 Prostaglandin E2 (PGE2) has been reported to exert different effects on tissues at low and high levels. In the present study, cell culture experiments were performed to determine the potential biphasic effects of PGE2 on human tendon stem/progenitor ...
Jianying Zhang, James H-C Wang
doaj +1 more source
مجله علمی دانشگاه علوم پزشکی کردستان, 2021 Aim and Background: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract against the inflammatory factors ...
zakieh keshavarzi +3 more
doaj
Frontiers in Network Physiology, 2023 Background: Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. The Munich Wistar Frömter (MWF) rat is a non-diabetic model of chronic kidney disease (CKD) with GH due to inherited low nephron ...
Debora Kaiser-Graf +5 more
doaj +1 more source
Apoptotic caspases cut down the immunogenicity of radiation
OncoImmunology, 2019 Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon ...
Aitziber Buqué +3 more
doaj +1 more source
Jurnal Anestesi Perioperatif, 2019 Analgesia multimodal adalah prinsip manajemen nyeri pascaoperasi. Penelitian ini merupakan uji klinis rancangan acak tersamar ganda. Tujuan penelitian ini membandingkan efek kombinasi analgesik tramadol dan deksketoprofen dengan tramadol dan parasetamol ...
Clara Valentia Josephine +3 more
doaj +1 more source