Results 61 to 70 of about 31,453,429 (295)

Candida albicans colonization modulates murine ethanol consumption and behavioral responses through elevation of serum prostaglandin E2 and impact on the striatal dopamine system

mBio
Candida albicans is a commensal yeast that is a common component of the gastrointestinal (GI) microbiome of humans. C. albicans has been shown to bloom in the GI tract of individuals with alcohol use disorder (AUD) and can promote and increase the ...
Andrew W. Day, Emma Hayes, Jeyra Perez-Lozada, Alyssa DiLeo, Katrina Blandino, Jamie Maguire, Carol A. Kumamoto   +6 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Oral administration of E-type prostanoid (EP) 1 receptor antagonist suppresses carcinogenesis and development of prostate cancer via upregulation of apoptosis in an animal model

Scientific Reports, 2021
Prostaglandin E2 plays an important role in carcinogenesis and malignant potential of prostate cancer (PC) cells by binding to its specific receptors, E-type prostanoid (EP) receptors.
Masahito Masato, Yasuyoshi Miyata, Hiroki Kurata, Hidenori Ito, Kensuke Mitsunari, Akihiro Asai, Yuichiro Nakamura, Kyohei Araki, Yuta Mukae, Tsuyoshi Matsuda, Junki Harada, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai   +13 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Prostaglandin E𝟐 and the Suppression of Phagocyte Innate Immune Responses in Different Organs

Mediators of Inflammation, 2012
The local and systemic production of prostaglandin E2 (PGE2) and its actions in phagocytes lead to immunosuppressive conditions. PGE2 is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E ...
Alexandra Medeiros, Camila Peres-Buzalaf, Felipe Fortino Verdan, C. Henrique Serezani   +3 more
doaj   +1 more source

Sensitization of TRPV1 by EP₁ and IP reveals peripheral nociceptive mechanism of prostaglandins

Molecular Pain, 2005
Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia. The role of their receptors (EP and IP, respectively) in inflammation has been well documented, although ...
Segi Eri, Iida Tohko, Togashi Kazuya, Higashi Tomohiro, Moriyama Tomoko, Sugimoto Yukihiko, Tominaga Tomoko, Narumiya Shuh, Tominaga Makoto   +8 more
doaj   +1 more source

Expression of E-prostanoid receptors in nasal polyp tissues of smoking and nonsmoking patients with chronic rhinosinusitis. [PDF]

PLoS ONE, 2018
BACKGROUND:Different inflammatory reactions have been observed in the polyp tissues of nonsmokers and smokers with chronic rhinosinusitis (CRS). E-prostanoid (EP) receptors play a role in the inflammatory processes.
Li Xie, Ai-Guo Liu, Li-Yan Peng, Su-Jie Wang, Yin-Ping Zhang, Xian-Song Wang   +5 more
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3 [PDF]

Nature Immunology, 2005
Prostaglandins, including PGD(2) and PGE(2), are produced during allergic reactions. Although PGD(2) is an important mediator of allergic responses, aspirin-like drugs that inhibit prostaglandin synthesis are generally ineffective in allergic disorders, suggesting that another prostaglandin-mediated pathway prevents the development of allergic ...
Tomonori, Kunikata, Hana, Yamane, Eri, Segi, Toshiyuki, Matsuoka, Yukihiko, Sugimoto, Satoshi, Tanaka, Hiroyuki, Tanaka, Hiroichi, Nagai, Atsushi, Ichikawa, Shuh, Narumiya   +9 more
openaire   +2 more sources

Regulation of microsomal prostaglandin E2 synthase by cyclopentenone prostaglandins in colon cancer cells [PDF]

, 2006
Prostaglandin E2 is the major prostaglandin involved in colorectal carcinogenesis. The biosynthesis of prostaglandin E2 is accomplished by several terminal prostaglandin E synthases through catalytical conversion of the cyclooxygenase product ...
Yudina, Yulyana
core