Results 11 to 20 of about 31,453,429 (295)
Regulation of renal function by prostaglandin E receptors [PDF]
Kidney International, 1998 Prostaglandin E2 is the major cyclooxygenase product of arachidonic acid metabolism produced along the nephron. This autacoid interacts with four distinct, G-protein-coupled E-prostanoid receptors designated EP1-EP4. The intrarenal distribution of each receptor has been mapped and the consequences of receptor activation examined.
Breyer, Matthew D. +5 more
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Prostaglandin E and F receptors in the uterus [PDF]
Receptors & Clinical Investigation, 2014 Prostaglandins (PGs) are necessary for normal female reproduction. PGs act via their respective receptors and execute various functions in their target tissues depending on which type of receptor being activated. PG receptors are G-protein coupled receptors mediating various vital processes in the uterus throughout the reproductive cycle and pregnancy.
Chellakkan Selvanesan Blesson, Lena Sahlin
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Prostaglandin E receptors and the kidney
American Journal of Physiology-Renal Physiology, 2000 Prostaglandin E2is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP1, EP2, EP3, and EP4. Through these receptors, PGE2modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized,
M D, Breyer, R M, Breyer
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American Journal of Physiology-Endocrinology and Metabolism, 1981 Up-regulation in vivo of liver plasma membrane receptors for prostaglandin E (PGE) was studied in Sprague-Dawley rats using the prostaglandin synthesis inhibitors, acetylsalicylic acid (ASA) and indomethacin (Indo). Following 4 days of treatment with ASA, the concentration of receptors and the affinity for binding were both significantly increased (Ro -
M G, Rice +3 more
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Prostaglandin E Receptors [PDF]
Journal of Biological Chemistry, 2007 Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression ...
Yukihiko, Sugimoto, Shuh, Narumiya
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Prostaglandin EP4 receptors: a possible therapeutic target for endometriosis
, 2016 Prostaglandin EP4 receptors: a possible therapeutic target for ...
Garvin, JH +5 more
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Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]
, 2006 Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M. +9 more
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Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]
, 2009 Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C. +6 more
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Journal of Neuroinflammation, 2017 Background Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers ...
Alyssa L. Pedersen, Colin J. Saldanha
doaj +1 more source
Prostaglandin E2 receptors in bone formation [PDF]
International Orthopaedics, 2007 Prostaglandins, PGE(2) in particular, have diverse actions on various organs, including inflammation, bone healing, bone formation, embryo implantation, induction of labour and vasodilatation, among others. However, systemic side effects have limited their clinical utility.
M, Li, D D, Thompson, V M, Paralkar
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