Results 21 to 30 of about 712,631 (292)

Prostaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4. [PDF]

PLoS ONE, 2014
BACKGROUND: Mast cells play a critical role in allergic and inflammatory diseases, including exercise-induced bronchoconstriction (EIB) in asthma. The mechanism underlying EIB is probably related to increased airway fluid osmolarity that activates mast ...
Ivonne Torres-Atencio, Erola Ainsua-Enrich, Fernando de Mora, César Picado, Margarita Martín   +4 more
doaj   +1 more source

Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis

Respiratory Research, 2006
Background Eicosanoid receptors are G-protein-coupled receptors playing an important immunomodulatory role in airway diseases. However, there is little information on the expression of these receptors and their link with eosinophilic inflammation in ...
Van Cauwenberge Paul, Claeys Cindy, Pérez-Novo Claudina, Bachert Claus   +3 more
doaj   +1 more source

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors [PDF]

, 2015
Understanding the regulation of T-cell responses during inflammation and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases.
Cuesta, Natalia, Manuel Fresno, Fresno, Manuel, Sancho, David, Miroslav Hons, Hons, Miroslav ; https://orcid.org/, Stein, Jens, Carmen Punzón, Stein, Jens V., Fresno Forcelledo, Manuel, Natalia Cuesta, Stein, Jens V, Hons, Miroslav, Vinatha Sreeramkumar, Stein, Jens Volker, Sreeramkumar, Vinatha, David Sancho, Cuesta Rubio, Natalia, Jens V Stein, Punzón, Carmen   +19 more
core   +1 more source

Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. [PDF]

PLoS ONE, 2014
The functional and molecular alterations of nerve growth factor (NGF) and Prostaglandin E2 (PGE2) and its receptors were studied in bladder and urine in streptozotocin (STZ)-induced diabetic rats.Diabetes mellitus was induced with a single dose of 45 mg ...
Jayabalan Nirmal, Pradeep Tyagi, Yao-Chi Chuang, Wei-Chia Lee, Naoki Yoshimura, Chao-Cheng Huang, Bharathi Rajaganapathy, Michael B Chancellor   +7 more
doaj   +1 more source

Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation

Frontiers in Pharmacology, 2022
Cortical information is transferred to the substantia nigra pars reticulata (SNr) and the entopeduncular nucleus (EP), the output structures of the basal ganglia (BG), through three different pathways: the hyperdirect trans-subthalamic and the direct and
Sergio Vegas-Suárez, Sergio Vegas-Suárez, Sergio Vegas-Suárez, Sergio Vegas-Suárez, Teresa Morera-Herreras, Teresa Morera-Herreras, Catalina Requejo, Catalina Requejo, José Vicente Lafuente, Rosario Moratalla, Rosario Moratalla, Cristina Miguélez, Cristina Miguélez, Luisa Ugedo, Luisa Ugedo   +14 more
doaj   +1 more source

Study on Strengthening Mechanism of Epoxy Resin/Rubber Concrete Interface by Molecular Dynamics Simulation

Advances in Civil Engineering, 2022
Rubber concrete has high environmental and economic benefits. However, the difference in the physical and chemical properties of the interface causes a weak interface between rubber and concrete, which limits the use of rubber concrete to a certain ...
Lijuan Li, Dajing Qin, Zhijun Xu, Yong Feng   +3 more
doaj   +1 more source

Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer’s disease [PDF]

Neuroscience Bulletin, 2010
Neuroinflammation has always been of concern in the pathogenesis of Alzheimer's disease (AD). As a major inflammatory mediator, prostaglandin E(2) (PGE(2)) plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE(2). However, the role of PGE(2) in neurodegeneration
Li-Li, Wei, Yue-Di, Shen, Ying-Chun, Zhang, Xing-Yue, Hu, Pei-Ling, Lu, Li, Wang, Wei, Chen   +6 more
openaire   +2 more sources

Sensitization of TRPV1 by EP₁ and IP reveals peripheral nociceptive mechanism of prostaglandins

Molecular Pain, 2005
Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia. The role of their receptors (EP and IP, respectively) in inflammation has been well documented, although ...
Segi Eri, Iida Tohko, Togashi Kazuya, Higashi Tomohiro, Moriyama Tomoko, Sugimoto Yukihiko, Tominaga Tomoko, Narumiya Shuh, Tominaga Makoto   +8 more
doaj   +1 more source

PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway

Immunity, Inflammation and Disease, 2022
Prostaglandin E2 (PGE2) is a potent lipid mediator of inflammation that modulates immune cell function by binding to unique G protein‐coupled receptors (EP receptors). PGE2 production increases during microbial infection and inflammation.
Zixuan Wang, Xinyuan Wei, Caili Ji, Wenhua Yu, Chuanwang Song, Caizhi Wang   +5 more
doaj   +1 more source