Results 21 to 30 of about 93,312 (311)

Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction [PDF]

, 2020
Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy.
Junyan Zhu, Viktoria von Schönfeldt, Lin, Peng, Jeschke, Udo, Ye, Yao, Zhu, Junyan, Yao Ye, Peng Lin, Udo Jeschke, von Schönfeldt, Viktoria   +9 more
core   +1 more source

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]

, 2007
Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration ...
Williams, A R, Battersby, S, Gardner, S, Jabbour, H N, Sales, K J, Anderson, R A   +5 more
core   +1 more source

The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors

FEBS Open Bio, 2022
EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways.
Keijo Fukushima, Kanaho Senoo, Naoki Kurata, John W. Regan, Hiromichi Fujino   +4 more
doaj   +1 more source

Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets

Frontiers in Medicine, 2017
Of the known prostanoid receptors, human eosinophils express the prostaglandin D2 (PGD2) receptors DP1 [also D-type prostanoid (DP)] and DP2 (also chemoattractant receptor homologous molecule, expressed on Th2 cells), the prostaglandin E2 receptors EP2 ...
Miriam Peinhaupt, Eva M. Sturm, Akos Heinemann   +2 more
doaj   +1 more source

Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion

International Journal of Cell Biology, 2012
Prostaglandins exert a profound influence over the adhesive, migratory, and invasive behavior of cells during the development and progression of cancer.
David G. Menter, Raymond N. DuBois
doaj   +1 more source

Roles of prostaglandin receptors in female reproduction [PDF]

Journal of Biochemistry, 2014
Prostaglandins (PGs) have long been known to play roles in various processes of female reproduction; however, the molecular mechanisms therein remained unsolved until recently. This review summarizes the recent progress towards understanding the molecular mechanisms underlying PG actions in fertilization and parturition.
Yukihiko, Sugimoto, Tomoaki, Inazumi, Soken, Tsuchiya   +2 more
openaire   +2 more sources

Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. [PDF]

PLoS ONE, 2014
The functional and molecular alterations of nerve growth factor (NGF) and Prostaglandin E2 (PGE2) and its receptors were studied in bladder and urine in streptozotocin (STZ)-induced diabetic rats.Diabetes mellitus was induced with a single dose of 45 mg ...
Jayabalan Nirmal, Pradeep Tyagi, Yao-Chi Chuang, Wei-Chia Lee, Naoki Yoshimura, Chao-Cheng Huang, Bharathi Rajaganapathy, Michael B Chancellor   +7 more
doaj   +1 more source

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Neurobiology of Disease, 2014
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine   +5 more
doaj   +1 more source

Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain

Journal of Neuroinflammation, 2017
Background Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers ...
Alyssa L. Pedersen, Colin J. Saldanha
doaj   +1 more source