Results 41 to 50 of about 93,312 (311)

Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors

, 2011
Activated human platelets synthesize prostaglandin (PG) E(2), although at lower rate than thromboxane A(2). PGE(2) acts through different receptors (EP1-4), but its role in human platelet function remains poorly characterized compared with thromboxane ...
De Cristofaro, Raimondo, Lancellotti, Stefano, Pocaterra, Davide, Rutella, S, Pocaterra, D, De Cristofaro, R, Rocca, B, Petrucci, G, Habib, A, Rutella, Sergio, Petrucci, Giovanna, Ranelletti, FO, Patrono, C, Lancellotti, S, Patrono, Carlo, Rocca, Bianca   +15 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Prostaglandins: Key players in immunomodulation of the nervous system

Neural Regeneration Research
As a class of bioactive substances that play important roles in a variety of physiological and pathological processes, prostaglandins have attracted increasing research attention.
Ziqin Wang, Ying Sun, Minjie Luo, Nina He, Zhongchi Wen, Zuzhen Wang, Yonglong Zhang, Jie Zhao, Ying Liu   +8 more
doaj   +1 more source

Prostaglandin E2 regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors

Journal of Lipid Research, 2000
Inflammatory responses are thought to be mediated in part by the prostaglandins derived from arachidonic acid (AA) by the action of prostaglandin H synthase, also referred to as cyclooxygenase (COX).
Regina E. Maldve, Youngsoo Kim, Stephanie J. Muga, Susan M. Fischer   +3 more
doaj   +1 more source

Docking for EP4R antagonists active against inflammatory pain

Nature Communications, 2023
The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R).
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet   +18 more
doaj   +1 more source

Antinociceptive activity of the S1P-receptor agonist FTY720

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Geisslinger, Gerd, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Sandra Pierre, Brenneis, Christian, Ovidiu Coste, Claudiu Marian, Marian, Claudiu, Popp, Laura, Coste, Ovidiu, Carlo Angioni, Schmidt, Helmut, Christian Brenneis, Pierre, Sandra, Helmut Schmidt   +17 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A bioprinted model of pregnant human uterine myometrium

Frontiers in Bioengineering and Biotechnology
Despite decades of research, complications associated with dysfunctional labor are leading causes of maternal and neonatal morbidity. Currently available experimental models are not sufficient to understand the complex mechanisms underlying human labor ...
Craig Ulrich, Korrina Siddiqui, Lexa K. Baldwin, Weijian Hua, Jacob K. Kuklok, Jada J. Okaikoi, Lauren L. Parker, Juli Petereit, Dave R. Quilici, Grace M. Silva, Grace M. Silva, Anutr Sivakoses, Anutr Sivakoses, Anutr Sivakoses, Jiavanna S. Wong-Fortunato, Rebekah J. Woolsey, Adrian West, Adrian West, Yifei Jin, Heather Burkin, Heather Burkin   +20 more
doaj   +1 more source

REDUCING PERIPHERAL INFLAMMATION WITH INFLIXIMAB REDUCES NEUROINFLAMMATION AND IMPROVES COGNITION IN RATS WITH HEPATIC ENCEPHALOPATHY

Frontiers in Molecular Neuroscience, 2016
Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear.
Vicente Felipo
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source