Results 61 to 70 of about 674,548 (295)
The Roles of Various Prostaglandins in Fibrosis: A Review
Biomolecules, 2021 Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired ...
Ke Li +6 more
doaj +1 more source
Regulation of microsomal prostaglandin E2 synthase by cyclopentenone prostaglandins in colon cancer cells [PDF]
, 2006 Prostaglandin E2 is the major prostaglandin involved in colorectal carcinogenesis. The biosynthesis of prostaglandin E2 is accomplished by several terminal prostaglandin E synthases through catalytical conversion of the cyclooxygenase product ...
Yudina, Yulyana
core
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
NEW INSIGHTS AND POSSIBLE THERAPEUTIC IMPLICATIONS OF ADENOSINE ANALOGS AND PULSED ELECTROMAGNETIC FIELDS (PEMFs) IN OSTEOARTICULAR PATHOLOGIES [PDF]
, 2009 Objective: The aim of this study was to characterize adenosine receptors in synovial fibroblasts (SFs) and to investigate the potential link between adenosine pathway and pulsed electromagnetic fields (PEMFs).
Masieri, Federica Francesca
core
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
Physiological ReportsPulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism
J. Hanusrichterova +14 more
doaj +1 more source
An electrophysiological study of the interaction between fenamate NSAIDs and the GABA(_A) receptor [PDF]
, 1999 The effects of certain NSAIDs were determined on agonist-evoked responses recorded from rat neurones maintained in vitro using electrophysiological techniques. Initially, the rat isolated vagus and optic nerves were employed. Alphaxalone, pentobarbitone,
Patten, Debra
core
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Ligand-based machine learning models to classify active compounds for prostaglandin EP2 receptor
Scientific ReportsProstaglandin receptors are pharmacologically validated targets with implications in several medical indications, including glaucoma, cardiac cyanotic disease, pulmonary hypertension, oncology, and various rare diseases.
Paul Dupuyds +7 more
doaj +1 more source