Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition [PDF]
Frontiers in ImmunologyAdoptive Natural Killer (NK) cell transfer is a promising therapy for the treatment of cancer. We developed a GMP-compliant protocol to generate NK cells from hematopoietic stem and progenitor cells (HSPC-NK).
Marcos Vidal-Manrique +11 more
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Discovery and Characterization of Carbamothioylacrylamides As EP2 Selective Antagonists
ACS Medicinal Chemistry Letters, 2013 Prostanoid receptor EP2 is emerging as a novel target for development of anti-inflammatory drugs for the treatment of chronic neurodegenerative and peripheral diseases; however, the availability of EP2 antagonist probes for exploration of peripheral disease models is very limited.
Ray Dingledine +2 more
exaly +4 more sources
Structural insights into selective and dual antagonism of EP2 and EP4 prostaglandin receptors [PDF]
The EMBO JournalProstaglandin E2 (PGE2) signaling through EP2 and EP4 receptors is crucial in regulating inflammation, pain, and cancer progression. While selective and dual antagonists for these receptors hold therapeutic potential, their binding mechanisms and ...
Yanli Wu +8 more
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Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice [PDF]
The Journal of Clinical InvestigationOrphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor
Jeonghyeon Kwon +9 more
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Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2 [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Prostaglandin E2 E-prostanoid 2 receptor (PGE2 EP2), downstream of cyclooxygenase-2 (COX-2), plays an important role in inflammatory responses, but there are some reports about synaptic functions of COX-2 and PGE2 EP2 in the hippocampus ...
Hyo Young Jung +10 more
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Numerical treatment of a magnetized electron fluid model in a 3D simulator of plasma thruster plumes
Frontiers in Physics, 2023 Simulations of energetic plumes from plasma thrusters are of great interest for estimating performances and interactions with the spacecraft. Both in fully fluid and hybrid (particle/fluid) models, the electron population is described by a set of fluid ...
Alberto Modesti +2 more
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Magnetic Nozzle and RPA Simulations vs. Experiments for a Helicon Plasma Thruster Plume
Frontiers in Physics, 2022 The experimental characterization of electrodeless plasma thrusters with a magnetic nozzle is fundamental in the process of increasing their maturity to reach the industrialization level.
Filippo Cichocki +3 more
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Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR. [PDF]
PLoS ONE, 2017 G protein-coupled receptors (GPCRs) have been found to form heterodimers and modulate or fine-tune the functions of GPCRs. However, the involvement of GPCR heterodimerization and its functional consequences in gonadal tissues, including granulosa cells ...
Shin Matsubara +4 more
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Frontiers in Immunology, 2021 Prostaglandin E2 (PGE2) is a lipid mediator that modulates the function of myeloid immune cells such as macrophages and dendritic cells (DCs) through the activation of the G protein-coupled receptors EP2 and EP4. While both EP2 and EP4 signaling leads to
Ward Vleeshouwers +6 more
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Reproductive Medicine and Biology, 2022 Purpose While the prevailing view holds that the prostaglandin E2 (PGE2) signaling plays a vital role in endometriosis, PGE2 also is known to be anti‐fibrotic.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
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