Results 21 to 30 of about 11,193 (295)

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis [PDF]

, 2017
Endometriosis is an incurable gynecological disorder characterized by debilitating pain and the establishment of innervated endometriosis lesions outside the uterus. In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE2-
Mikolajczak, Marta, Saunders, Philippa T. K., Jerina, Helen, Erin Greaves, Greaves, Erin, Helen Jerina, Andrew W. Horne, Saunders, Philippa T. K.; id_orcid, Hilferty, Lisa, Fleetwood-Walker, Sue M., Philippa T. K. Saunders, Sue M. Fleetwood-Walker, Horne, Andrew W., Mitchell, Rory, Marta Mikolajczak, Rory Mitchell, Lisa Hilferty   +16 more
core   +1 more source

The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors

FEBS Open Bio, 2022
EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways.
Keijo Fukushima, Kanaho Senoo, Naoki Kurata, John W. Regan, Hiromichi Fujino   +4 more
doaj   +1 more source

Contrasting Mesoscale Convective System Features of Two Successive Warm-Sector Rainfall Episodes in Southeastern China: A Satellite Perspective

Remote Sensing, 2022
Based on Himawari-8 satellite observations, the mesoscale convective system (MCS) behaviors of two successive but distinct warm-sector rainfall episodes (EP1 and EP2) on 6–7 May 2018 over southeastern China were compared, with the latter episode being a ...
Yipeng Huang, Murong Zhang
doaj   +1 more source

Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage

Bioscience Reports, 2014
The prostaglandin E2 receptor, EP2 (E-prostanoid 2), plays an important role in mice glomerular MCs (mesangial cells) damage induced by TGFβ1 (transforming growth factor-β1); however, the molecular mechanisms for this remain unknown.
Na‑Na Li, Yu‑Yin Xu, Xiao‑Lan Chen, Ya‑Ping Fan, Jian‑Hua Wu   +4 more
doaj   +1 more source

Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor‐dependent activation of β‐catenin in 5/6 nephrectomy rats

ESC Heart Failure, 2021
Aims Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated.
Yaqiong Wang, Ting Zhang, Xuesen Cao, Jianzhou Zou, Xiaoqiang Ding, Bo Shen, Wenlv Lv   +6 more
doaj   +1 more source

Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells [PDF]

, 2009
Uterine fibroids are benign tumors that arise from the smooth-muscle uterine cells (myometrium) and are the most common uterine disorder occurring in as many as 30% of women over 35 years of age. Despite their frequent occurrence, the etiology of uterine
Abera, Aron Berhanie
core   +1 more source

Human Amniotic Membrane Mesenchymal Stem Cell-Synthesized PGE₂ Exerts an Immunomodulatory Effect on Neutrophil Extracellular Trap in a PAD-4-Dependent Pathway through EP2 and EP4

Cells, 2022
Human amniotic membrane mesenchymal stem cells (hAM-MSC) secrete a myriad of components with immunosuppressive activities. In the present research, we aimed to describe the effect of prostaglandin E2 (PGE2) secreted by hAM-MSCs on neutrophil ...
Gibrán Alejandro Estúa-Acosta, Beatriz Buentello-Volante, Fátima Sofía Magaña-Guerrero, José Eduardo-Aguayo Flores, Oscar Vivanco-Rojas, Ilse Castro-Salas, Karla Zarco-Ávila, Mariana A. García-Mejía, Yonathan Garfias   +8 more
doaj   +1 more source

The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases [PDF]

, 2020
Recently our study identified EP3 receptor and galectin-3 as prognosticators of cervical cancer. The aim of the present study was the analysis of EP2 as a novel marker and its association to EP3, galectin-3, clinical pathological parameters and the ...
Gallwas, Julia, Jeschke, Udo, Ye, Yao, Mahner, Sven, Kuhn, Christina, Vattai, Aurelia, Schröder, Lennard, Heidegger, Helene Hildegard, Dietlmeier, Sebastian, Kost, Bernd P., Vilsmaier, Theresa   +10 more
core   +1 more source

Validación preclínica del receptor EP2 mastocitario como diana terapéutica antiasmática [PDF]

, 2016
El asma es una enfermedad crónica de las vías respiratorias cuyo abordaje terapéutico actual no frena su progresión, y en ocasiones no revierte la sintomatología.
Plaza Almolda, Judith, Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia   +1 more
core   +3 more sources