Results 41 to 50 of about 11,193 (295)

EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells

Frontiers in Immunology
Tumors educate their environment to prime the occurrence of suppressive cell subsets, which enable tumor evasion and favors tumor progression. Among these, there are the myeloid-derived suppressor cells (MDSCs), their presence being associated with the ...
Jorge Cuenca-Escalona, Beatriz Subtil, Alba Garcia-Perez, Alessandra Cambi, I. Jolanda M. de Vries, Georgina Flórez-Grau   +5 more
doaj   +1 more source

A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection.

PLoS ONE, 2015
BackgroundSemen is a major vehicle for HIV transmission. Prostatic acid phosphatase (PAP) fragments, such as PAP248-286, in human semen can form amyloid fibrils to enhance HIV infection.
Jinquan Chen, Ruxia Ren, Suiyi Tan, Wanyue Zhang, Xuanxuan Zhang, Fei Yu, Tianrong Xun, Shibo Jiang, Shuwen Liu, Lin Li   +9 more
doaj   +1 more source

Novel Microglia Cell Line Expressing the Human EP2 Receptor

, 2019
Recently, EP2 signaling pathways were shown to regulate the classical activation and death of microglia in rat primary microglial culture. The study of microglial cells has been challenging because they are time-consuming to isolate in culture, they are ...
Di Chen (15424), Avijit Banik, Thota Ganesh (1319988), Asheebo Rojas (7372196), Thota Ganesh, Kevin Flood (7372199), Kevin Flood, Raymond Dingledine, Di Chen, Avijit Banik (5919077), Raymond Dingledine (2417179), Asheebo Rojas   +11 more
core   +1 more source

From Green Governance to Biodiversity Strategy: The Role of Environmentally Experienced Directors in Chinese Firms

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates how directors with environmental protection (EP) backgrounds influence corporate biodiversity concern (BIO) among Chinese A‐share listed firms from 2008 to 2023. Drawing on Upper Echelons Theory, we argue that directors' environmental expertise shapes firms' biodiversity strategies.
Chengming Huang, Sultan Sikandar Mirza, Chengwei Zhang   +2 more
wiley   +1 more source

Digital Orientation and Green Practices in Chilean SMEs: Innovation as the Pathway to Competitive Performance

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how digital strategic orientation (DSO) and environmental practices (EP) interact to shape innovation and performance among Chilean SMEs. Using survey data from 271 firms (February–May 2022), we estimate a generalized structured component analysis (GSCA) model that accommodates a nonrecursive relationship between DSO and EP.
Constanza Caicha‐Caroca, Antonia Madrid‐Guijarro, Claudia Andrea Pezoa‐Fuentes   +2 more
wiley   +1 more source

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

Neurobiology of Disease, 2020
This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2–4 h ...
Asheebo Rojas, Thota Ganesh, Wenyi Wang, Jennifer Wang, Raymond Dingledine   +4 more
doaj   +1 more source

The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke [PDF]

, 2010
Background The prostaglandin E2 EP2 receptor has been shown to be important in dictating outcomes in various neuroinflammatory disorders. Here, we investigated the importance of the EP2 receptor in short- and long-term ischemic outcomes by ...
Muzamil Ahmad, Shuh Narumiya, Zahoor Shah, Sylvain Doré, Takayuki Maruyama, Sofiyan Saleem   +5 more
core   +1 more source

Human Agency Drivers for Eco‐Innovation: The Role of Environmental Entrepreneurship Orientation and Green Human Resource Management

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how human agency drives eco‐innovation by analyzing the mediating role of green human resource management (HRM) in the relationship between environmental entrepreneurship orientation (EEO) and eco‐innovation. By integrating resource orchestration theory with the Ability–Motivation–Opportunity (AMO) framework, the study ...
Ana Labella‐Fernández, Diego A. Vazquez‐Brust, Javier Martínez‐del‐Río, Rui Yang   +3 more
wiley   +1 more source

An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons

Mediators of Inflammation, 2016
Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4.
Yoshinori Hayashi, Saori Morinaga, Xia Liu, Jing Zhang, Zhou Wu, Takeshi Yokoyama, Hiroshi Nakanishi   +6 more
doaj   +1 more source

Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity [PDF]

, 2020
Agonism of the prostaglandin E2 receptor, E-prostanoid receptor 2 (EP2), may represent an alternative protective mechanism in mast cell (MC)-mediated diseases.
Picado, César, Mora Pérez, Fernando de, Urbano, Adrián, Judith Plaza, Rosa Torres, Torres Blanch, Rosa, Adrián Urbano, Fernando de Mora, César Picado, Plaza, Judith   +9 more
core   +1 more source