Results 61 to 70 of about 11,193 (295)
Not a mouse stirring: deletion of the EP2 and love’s labor’s lost [PDF]
Journal of Clinical Investigation, 1999 Prostaglandin E2 (PGE2) has long been implicated as a proinflammatory mediator; indeed, inhibition of PGE2 formation is thought to underlie the actions of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors of the PGG/PGH synthase-2 enzyme, commonly termed cyclooxygenase-2 (COX-2) (1, 2).
S, Austin, G A, FitzGerald
openaire +2 more sources
Journal of Consumer Behaviour, EarlyView.ABSTRACT Many brands have added highly incongruent products to their product lines, such as Lay's Chicken and Waffles Potato Chips, Blueberry Cheerios, and Carrot Cake Oreos. This paper investigates how highly incongruent products influence the choice of pre‐existing items in the product line.
Brittney Stephenson +4 more
wiley +1 more source
Chemistry ProceedingsEndometrial cancer is one of the most common gynecological cancers, with new global cases of approximately 420,000 new cases and 98,000 global deaths annually.
Grace Adaji, Asmau Nasir Hamza
doaj +1 more source
PGE 2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
Life Science Alliance, 2020 Dysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE 2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could explain ...
Loka R Penke +9 more
doaj +1 more source
Development of second generation EP2 antagonists with high selectivity [PDF]
European Journal of Medicinal Chemistry, 2014 EP2 receptor has emerged as an important biological target for therapeutic intervention. In particular, it has been shown to exacerbate disease progression of a variety of CNS and peripheral diseases. Deletion of the EP2 receptor in mouse models recapitulates several features of the COX-2 inhibition, thus presenting a new avenue for anti-inflammatory ...
Thota, Ganesh +2 more
openaire +2 more sources
AI Chatbots Versus Human Agents for Customer Service: A Social Belonging Perspective
Journal of Consumer Behaviour, EarlyView.ABSTRACT Artificial intelligence (AI) has rapidly transformed customer service, leading to the widespread adoption of AI‐driven chatbots. Despite these advances, consumers consistently prefer human agents over AI chatbots, as documented in both academic research and industry reports. This research proposes a Social Belonging Perspective to explain this
Linwan Wu, Chi Zhang, Kai Tian
wiley +1 more source
Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus
Neurobiology of Disease, 2015 As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) mediates brain inflammation and injury in many chronic central nervous system (CNS) conditions including seizures and epilepsy, largely through its receptor subtype
Jianxiong Jiang +5 more
doaj +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Despite its prevalence, research on binge‐eating disorder (BED) outcomes for residential treatment remains limited. To address this research scarcity, we evaluated changes in ED behaviors and comorbid symptoms, including depression and anxiety, for patients with BED that received residential eating disorder (ED) care from a ...
Kiki M. Kline +3 more
wiley +1 more source
Genomics Data, 2015 Amyloid-β (Aβ) peptides accumulate in the brains of patients with Alzheimer's disease (AD), where they generate a persistent inflammatory response from microglia, the innate immune cells of the brain. The immune modulatory cyclooxygenase/prostaglandin E2
Jenny U. Johansson +4 more
doaj +1 more source
Inhibition of EP2 receptor suppresses tumor growth and chemoresistance of gastric cancer.
, 2022 Gastric cancer is one of the leading causes of cancer death in the world. Early diagnosis and effective chemotherapy are vital to reduce the overall mortality.
Liu, X +4 more
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