Results 11 to 20 of about 11,193 (295)
EP2 inhibition restores myeloid metabolism and reverses cognitive decline
Journal of Allergy and Clinical Immunology: Global, 2023 Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial.
Ryan Lushington, MS +4 more
doaj +2 more sources
EP2 Receptor Signaling Regulates Microglia Death [PDF]
Molecular Pharmacology, 2015 The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation is still unclear.
Yujiao Fu +5 more
openaire +4 more sources
ASN Neuro, 2015 Intracerebral hemorrhage (ICH) is a devastating type of stroke characterized by bleeding into the brain parenchyma and secondary brain injury resulting from strong neuroinflammatory responses to blood components.
Jenna L. Leclerc +4 more
doaj +2 more sources
Journal of Translational Medicine, 2019 Background and aims Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver failure (ACLF).
Yunyun Wang +6 more
doaj +2 more sources
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4. [PDF]
PLoS ONE, 2014 Prostaglandin E2 (PGE2) is a bioactive lipid mediator that exerts its biological function through interaction with four different subtypes of E-Prostanoid receptor namely EP1, EP2, EP3 and EP4.
Manigandan Lejeune +2 more
doaj +2 more sources
Characterising the pleiotropic activity and spatial dynamics of Prostaglandin EP2 receptor signalling [PDF]
, 2021 EP2 is a member of the G protein coupled receptor superfamily and is implicated in both physiological and pathophysiological signalling in reproductive tissues.
Walker, Abigail
core +1 more source
Journal of Neuroinflammation, 2021 Background Alzheimer’s disease (AD) causes substantial medical and societal burden with no therapies ameliorating cognitive deficits. Centralized pathologies involving amyloids, neurofibrillary tangles, and neuroinflammatory pathways are being ...
Avijit Banik +6 more
doaj +1 more source
Reproductive Medicine and Biology, 2022 Purpose We investigated the change, if any, in prostaglandin E2 (PGE2) signaling in endometriotic lesions of different developmental stages in mouse.
Qingqing Huang, Xishi Liu, Sun‐Wei Guo
doaj +1 more source
Marine Drugs, 2020 The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid (GlcA), xylose (Xyl), and rhamnose (Rha).
Yingjuan Liu +3 more
doaj +1 more source
Prostaglandin E2 Receptor 2 Modulates Macrophage Activity for Cardiac Repair
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Prostaglandin E2 has long been known to be an immune modulator. It is released after tissue injury and plays a role in modulating macrophage activities, which are essential for tissue regeneration.
Jasmine M. F. Wu +5 more
doaj +1 more source