Results 81 to 90 of about 93,312 (311)

Differentiation of naive human CD4+ T cells into Th2 cells: The role of prostaglandin E2

Allergology International, 1999
T-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the development of human allergic diseases.
Kenji Katamura
doaj   +1 more source

Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells

, 2009
Uterine fibroids are benign tumors that arise from the smooth-muscle uterine cells (myometrium) and are the most common uterine disorder occurring in as many as 30% of women over 35 years of age. Despite their frequent occurrence, the etiology of uterine
Abera, Aron Berhanie
core  

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

PG F2alpha receptor: a promising therapeutic target for cardiovascular disease

Frontiers in Pharmacology, 2010
Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation and cardiovascular homeostasis.
Jian Zhang, Yanjun Gong, Ying Yu
doaj   +1 more source

Prostaglandins and Their Receptors: Implications for Ovarian Physiology

Neurosignals, 1996
The ovarian response to the stimulatory actions of pituitary gonadotropins is modulated by the local production and action of local factors. Current advances in biochemical and molecular research techniques have facilitated the progress in our understanding of how prostaglandins (PGs) are inherently involved in the physiological events influencing ...
J I, Olofsson, P C, Leung
openaire   +2 more sources

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Prostaglandin EP4 receptors: a possible therapeutic target for endometriosis

, 2016
Prostaglandin EP4 receptors: a possible therapeutic target for ...
Garvin, JH, Crosbie, Emma; id_orcid, Marshall, Kay; id_orcid, Rosser, Matthew, Zarroug, Osman, Fischer, Deborah   +5 more
core   +1 more source

Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors

, 2015
Understanding the regulation of T-cell responses during inflammation and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases.
Cuesta, Natalia, Manuel Fresno, Fresno, Manuel, Sancho, David, Miroslav Hons, Hons, Miroslav ; https://orcid.org/, Stein, Jens, Carmen Punzón, Stein, Jens V., Fresno Forcelledo, Manuel, Natalia Cuesta, Stein, Jens V, Hons, Miroslav, Vinatha Sreeramkumar, Stein, Jens Volker, Sreeramkumar, Vinatha, David Sancho, Cuesta Rubio, Natalia, Jens V Stein, Punzón, Carmen   +19 more
core   +1 more source