Results 101 to 110 of about 674,548 (295)

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors [PDF]

, 2015
Understanding the regulation of T-cell responses during inflammation and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases.
Cuesta, Natalia, Manuel Fresno, Fresno, Manuel, Sancho, David, Miroslav Hons, Hons, Miroslav ; https://orcid.org/, Stein, Jens, Carmen Punzón, Stein, Jens V., Fresno Forcelledo, Manuel, Natalia Cuesta, Stein, Jens V, Hons, Miroslav, Vinatha Sreeramkumar, Stein, Jens Volker, Sreeramkumar, Vinatha, David Sancho, Cuesta Rubio, Natalia, Jens V Stein, Punzón, Carmen   +19 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation

Frontiers in Bioscience-Landmark
Background: Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms responsible for such dysregulation have been elusive.
Michael R. Odom, Francis M. Hughes Jr., NiQuava Pope, Huixia Jin, J. Todd Purves   +4 more
doaj   +1 more source

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1

Frontiers in Aging Neuroscience, 2019
Alzheimer’s disease (AD) is reportedly associated with the accumulation of calcium ions (Ca2+), and this accumulation is responsible for the phosphorylation of tau.
Long-Long Cao, Pei-Pei Guan, Yun-Yue Liang, Xue-Shi Huang, Pu Wang   +4 more
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Candida albicans colonization modulates murine ethanol consumption and behavioral responses through elevation of serum prostaglandin E2 and impact on the striatal dopamine system

mBio
Candida albicans is a commensal yeast that is a common component of the gastrointestinal (GI) microbiome of humans. C. albicans has been shown to bloom in the GI tract of individuals with alcohol use disorder (AUD) and can promote and increase the ...
Andrew W. Day, Emma Hayes, Jeyra Perez-Lozada, Alyssa DiLeo, Katrina Blandino, Jamie Maguire, Carol A. Kumamoto   +6 more
doaj   +1 more source

Functional characterization of eicosanoid signaling in Drosophila development.

PLoS Genetics
20-carbon fatty acid-derived eicosanoids are versatile signaling oxylipins in mammals. In particular, a group of eicosanoids termed prostanoids are involved in multiple physiological processes, such as reproduction and immune responses.
Daiki Fujinaga, Cebrina Nolan, Naoki Yamanaka   +2 more
doaj   +1 more source

Regulation of Immune Cells by Eicosanoid Receptors

The Scientific World Journal, 2007
Eicosanoids are potent, bioactive, lipid mediators that regulate important components of the immune response, including defense against infection, ischemia, and injury, as well as instigating and perpetuating autoimmune and inflammatory conditions ...
Nancy D. Kim, Andrew D. Luster
doaj   +1 more source