Results 31 to 40 of about 674,548 (295)

Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells [PDF]

, 2009
Uterine fibroids are benign tumors that arise from the smooth-muscle uterine cells (myometrium) and are the most common uterine disorder occurring in as many as 30% of women over 35 years of age. Despite their frequent occurrence, the etiology of uterine
Abera, Aron Berhanie
core   +1 more source

Synthesis and Biological Properties of Novel Fluoroprostaglandin Derivatives: Highly Selective and Potent Agonists for Prostaglandin Receptors

CHIMIA, 2004
Synthesis of novel 7,7-difluoroprostacyclin and 15-deoxy-15,15-difluoro-PGF2? derivatives will be presented. These compounds show high affinity to prostaglandin receptors and potent biological activities.
Yasushi Matsumuraa, Takashi Nakanob, Nobuaki Moria, Yoshitomi Morizawab   +3 more
doaj   +1 more source

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Neurobiology of Disease, 2014
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine   +5 more
doaj   +1 more source

Functional and molecular characterization of hyposensitive underactive bladder tissue and urine in streptozotocin-induced diabetic rat. [PDF]

PLoS ONE, 2014
The functional and molecular alterations of nerve growth factor (NGF) and Prostaglandin E2 (PGE2) and its receptors were studied in bladder and urine in streptozotocin (STZ)-induced diabetic rats.Diabetes mellitus was induced with a single dose of 45 mg ...
Jayabalan Nirmal, Pradeep Tyagi, Yao-Chi Chuang, Wei-Chia Lee, Naoki Yoshimura, Chao-Cheng Huang, Bharathi Rajaganapathy, Michael B Chancellor   +7 more
doaj   +1 more source

Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage

Bioscience Reports, 2014
The prostaglandin E2 receptor, EP2 (E-prostanoid 2), plays an important role in mice glomerular MCs (mesangial cells) damage induced by TGFβ1 (transforming growth factor-β1); however, the molecular mechanisms for this remain unknown.
Na‑Na Li, Yu‑Yin Xu, Xiao‑Lan Chen, Ya‑Ping Fan, Jian‑Hua Wu   +4 more
doaj   +1 more source

Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain

Journal of Neuroinflammation, 2017
Background Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers ...
Alyssa L. Pedersen, Colin J. Saldanha
doaj   +1 more source

Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis

Translational Neurodegeneration, 2023
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cord is a focus ...
Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Prostaglandin EP Receptors Involved in Modulating Gastrointestinal Mucosal Integrity

Journal of Pharmacological Sciences, 2010
.: Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the gastrointestinal tract, and E type PGs are most effective in these actions.
Koji Takeuchi, Shinichi Kato, Kikuko Amagase   +2 more
doaj   +1 more source

Expression of Prostaglandin E Receptors in Acquired Middle Ear Cholesteatoma [PDF]

Clinical and Experimental Otorhinolaryngology, 2018
Objectives To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. Methods Specimens of human acquired cholesteatoma
Sujie Wang, Li Xie, Yanfei Zhang, Pengfei Xu, Aiguo Liu   +4 more
doaj   +1 more source