Results 181 to 190 of about 371,177 (386)

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Sequential combination therapy with parenteral prostacyclin in BMPR2 mutations carriers

Pulmonary Circulation, 2022
Athénaïs Boucly, Laurent Savale, Xavier Jaïs, Marc Humbert, Olivier Sitbon, David Montani   +5 more
doaj   +1 more source

THE USE OF PROSTAGLANDIN F_2α GIVEN BY EITHER INTRAUTERINE INFUSION OR BY INTRAMUSCULAR INJECTION FOR THE CONTROL OF OESTRUS AND OVULATION IN CATTLE [PDF]

, 1975
N. W. MOORE
openalex   +1 more source

Diclofenac Detection via Inner‐Filter Effect Using Pyridine‐Modified Triphenylene

ChemPlusChem, EarlyView.
The synthesis of hexa‐pyridine triphenylene derivatives via Suzuki‐coupling reaction and their application toward the sensing of diclofenac have been studied for the first time. The 3PY and 4PY are selective for diclofenac over the other commonly prescribed pharmaceuticals and hormones tested. Triphenylene derivatives 3PY (2,3,6,7,10,11‐hexa(pyridine‐3‐
Navdeep Kajal, Amar Raj, Rajendhraprasad Tatikonda, Jan Lundell, Matti Haukka   +4 more
wiley   +1 more source

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market.
Paola Rizzarelli, Melania Leanza, Marco Rapisarda   +2 more
wiley   +1 more source

Synthesis of 19‐Hydroxyarachidonic Acid by Fungal Peroxygenases: An Experimental and Computational Study

ChemSusChem, EarlyView.
An experimental and computational investigation on the regio‐ and enantioselective hydroxylation of arachidonic acid by several unspecific peroxygenases (UPOs) revealed rAaeUPO A77L variant as the most attractive candidate for the selective production of valuable hydroxy‐fatty acids because of its enhanced regio and enantioselectivity and reduced ...
Alejandro González‐Benjumea, Mireia Martínez‐Sugrañes, Miguel Alcalde, Elvira Romero, Víctor Guallar, Martin Floor, Angel T. Martínez, Ana Gutiérrez   +7 more
wiley   +1 more source

Urinary prostaglandin metabolites as biomarkers for human labour: Insights into future predictors. [PDF]

PLoS One
Wood EM, Hornaday KK, Newton M, Wang M, Wood SL, Slater DM.   +5 more
europepmc   +1 more source

A Telescoped Strategy for the Preparation of Five‐Membered Hetero‐ and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow

ChemSusChem, EarlyView.
Pyrroles, thiophenes, and cyclopentenones are vital in drug discovery, yet their synthesis via diversity oriented synthesis is limited. Herein, a modular platform is developed for the scalable, telescoped synthesis of named structures in continuous flow by streamlining photocatalyzed hydrogen atom transfer and Paal–Knorr or Hunsdiecker condensation ...
Filippo Sacchelli, Elena Quadri, Luna Raineri, Alexandra Jorea, Marzia Pessina, Anna Lo Presti, Nicola Della Ca’, Davide Ravelli, Luca Capaldo   +8 more
wiley   +1 more source

Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to <i>in vitro</i> and <i>in vivo</i> inflammation models. [PDF]

Front Pharmacol
Huang Y, Wang M, Yang Z, Wang X, Wang X, He F.   +5 more
europepmc   +1 more source