Results 301 to 310 of about 243,841 (348)
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Gastroenterology Clinics of North America, 2001
PGs are important mediators of normal physiology, response to injury, and pathologic processes. Dissecting these biochemical and molecular pathways allows development of therapeutic agents that can be [figure: see text] applied to specific clinical situations, while preserving PGs that play a role in normal physiology.
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PGs are important mediators of normal physiology, response to injury, and pathologic processes. Dissecting these biochemical and molecular pathways allows development of therapeutic agents that can be [figure: see text] applied to specific clinical situations, while preserving PGs that play a role in normal physiology.
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JAMA: The Journal of the American Medical Association, 1975
The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In
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The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In
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Acta Obstetricia et Gynecologica Scandinavica, 1979
Abstract. The prostaglandins and some related substances of biological importance constitute a rapidly growing family of compounds, all the members of which are oxygenated derivatives of certain polyunsaturated, essential fatty acids, such as arachidonic acid.
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Abstract. The prostaglandins and some related substances of biological importance constitute a rapidly growing family of compounds, all the members of which are oxygenated derivatives of certain polyunsaturated, essential fatty acids, such as arachidonic acid.
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Prostaglandins & Other Lipid Mediators, 2002
Newly synthesized prostaglandins (PGs) efflux from cells by simple diffusion, driven by pH and the membrane potential. Metabolic clearance requires energy-dependent uptake across the plasma membrane, followed by cytoplasmic oxidation. Several PG carriers have been cloned and characterized. PGT is broadly expressed in cyclooxygenase (COX)-positive cells,
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Newly synthesized prostaglandins (PGs) efflux from cells by simple diffusion, driven by pH and the membrane potential. Metabolic clearance requires energy-dependent uptake across the plasma membrane, followed by cytoplasmic oxidation. Several PG carriers have been cloned and characterized. PGT is broadly expressed in cyclooxygenase (COX)-positive cells,
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Neuroscience Research, 1997
Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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Prostaglandin D2 (PGD2) is the endogenous sleep inducing substance in rats, mice, monkeys and probably in humans. PGD synthase (PGDS), the enzyme that produces PGD2 in the brain, is the key enzyme in sleep regulation. When the enzyme activity is inhibited by its specific inhibitor, SeCl4 in vivo, rats can no longer sleep.
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