Results 121 to 130 of about 19,015,309 (380)

Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Angewandte Chemie International Edition, EarlyView.
A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt, Yassmine El Harraoui, Alex Rothemann, Adrian T. Jauch, Sigrid Müller‐Deubert, Martin F. Köllen, Timo Risch, Lianne JHC Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Nina C. Bach, Stephan A. Sieber   +14 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

A note on the connectivity of 2-polymatroid minors [PDF]

arXiv, 2019
Brylawski and Seymour independently proved that if $M$ is a connected matroid with a connected minor $N$, and $e \in E(M) - E(N)$, then $M \backslash e$ or $M / e$ is connected having $N$ as a minor. This paper proves an analogous but somewhat weaker result for $2$-polymatroids.
arxiv  

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immue systems towards a T_H2-dominated response

Allergy, Asthma & Clinical Immunology, 2009
Pollen allergy is characterized by a TH2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances.
Gilles Stefanie, Mariani Valentina, Bryce Martina, Mueller Martin J, Ring Johannes, Behrendt Heidrun, Jakob Thilo, Traidl-Hoffmann Claudia   +7 more
doaj   +1 more source

Price of Anarchy with Heterogeneous Latency Functions [PDF]

arXiv, 2014
In this paper we consider the price of anarchy (PoA) in multi-commodity flows where the latency or delay function on an edge has a heterogeneous dependency on the flow commodities, i.e. when the delay on each link is dependent on the flow of individual commodities, rather than on the aggregate flow.
arxiv  

On the Exponent Conjectures [PDF]

arXiv, 2020
If $p$ is an odd prime, then we prove that $\e(H_2(G,\mathbb{Z})) \mid p\ \e(G)$ for $p$ groups of class 7. We prove the same for $p$ groups of class at most $p+1$ with $\e(Z(G))=p$. We also prove Schurs conjecture if $\e(G/Z(G))$ is $2,3$ or $6$. Furthermore we prove that if $G$ is a solvable group of derived length $d$ and $\e(G)=p$, then $\e(H_2(G ...
arxiv  

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post‐translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK) and its regulator Sirt5 in OA development ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Biosíntesis de los productos del ácido araquidónico y su repercusión sobre la inflamación

Revista Cubana de Estomatología, 1998
La liberación de ácido araquidónico o de otros ácidos grasos insaturados de 20 átomos de carbono, el icosatrienoico y el ecosapentanoico, de las reservas hísticas, es la primera fase de la síntesis de las prostaglandinas, tromboxanos y leucotrienos.
Andrés O Pérez Ruiz, . Liulia Cartaya Padrón, Víctor Valencia Fernández, Vivian Sanjurjo Gámez, Teresita Ilisástigui Ortueta   +4 more
doaj