Results 201 to 210 of about 52,245 (306)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Total oxylipin concentrations in NIST SRM 1950 plasma compared to fresh and commercially obtained human plasma. [PDF]

J Lipid Res
Kampschulte N, Scholz L, Pedersen TL, Snodgrass IF, Newman JW, Schebb NH.   +5 more
europepmc   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Xiebai San Alleviates Allergic Pulmonary Inflammation by Modulating Arachidonic Acid Metabolism. [PDF]

Pharmaceuticals (Basel)
Yue X, Han J, Pan C, Zhang Y, Liu S, Gao F, Zhao Y, Wu J, Wang Y, Cheng X, Liang A.   +10 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Hypothalamic Prostaglandins Facilitate Recovery From Severe Hypoglycemia but Exacerbate Recurrent Hypoglycemia in Mice. [PDF]

Diabetes
Abe T, Xu S, Sugiura Y, Arima Y, Hayasaka T, Lee ML, Ishimoto T, Araki Y, Ngurari S, Niu Z, Iijima N, Diano S, Toda C.   +12 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers. [PDF]

Nature
Buissant des Amorie JR, Hageman JH, Brunner SR, van der Horst SEM, Puschhof MC, van Hoeck A, van Lierop I, Middelkamp S, van der Schee L, van Kempen S, Morsink F, Geene R, Mertens S, Cavigelli DS, Verlaan-Klink I, Kraaier LJ, Salij J, Bezemer R, Kranenburg O, Laclé MM, Moons LMG, Snippert HJG.   +21 more
europepmc   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

Structural basis for prostaglandin and drug transport via SLCO2A1. [PDF]

Nat Commun
Joshi C, Deme JC, Nakamura Y, Hsu WT, Goult JD, Kato T, Parker JL, Biggin PC, Lea SM, Nakanishi T, Newstead S.   +10 more
europepmc   +1 more source