Results 141 to 150 of about 1,807,537 (411)
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Laparoscopic versus open radical prostatectomy in high prostate volume cases: impact on oncological and functional results [PDF]
, 2016 To prospectively compare the laparoscopic versus open approach to RP in cases with high prostate volume and to evaluate a possible diferente impact of prostate ...
Andrea, Fasulo +8 more
core +1 more source
Nature Communications, 2018 Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI)
Hao Geng +16 more
doaj +1 more source
JAMA Oncology, 2019 Importance The anti–programmed cell death protein 1 (PD-1) antibody pembrolizumab is approved by the US Food and Drug Administration for the treatment of microsatellite instability–high (MSI-H) or mismatch repair–deficient (dMMR) solid tumors, but the ...
W. Abida +30 more
semanticscholar +1 more source
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis [PDF]
, 2016 BACKGROUND: It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results ...
Cook, Michael B +6 more
core +3 more sources
Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort
Prostate Cancer, 2011 Introduction. Concern regarding overtreatment of prostate cancer (CaP) is leading to increased attention on active surveillance (AS). This study examined CaP survivors on AS and compared secondary treatment patterns and overall survival by race/ethnicity.
Jennifer Cullen +6 more
doaj +1 more source
The long tail of oncogenic drivers in prostate cancer
Nature Genetics, 2018 Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others.
J. Armenia +39 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Oral ethinylestradiol in castration resistent prostate cancer: 10 year experience [PDF]
, 2015 To describe our 10-year experience with the use of oral ethinylestradiol in the treatment of metastatic castration-resistant prostate cancer. METHODS: From February 2000 to April 2010, 116 patients with a metastatic castration-resistant prostate cancer
Aggarwal +16 more
core +1 more source