Results 261 to 270 of about 1,302,201 (345)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Proteomic Profiling of Extracellular Vesicles Distinguishes Prostate Cancer Molecular Subtypes. [PDF]

J Extracell Vesicles
Ludwig ML, Arafa AT, Vinoo S, Jones JC, Day A, Bergom HE, Sychev Z, Horrmann A, Levinson NM, Dehm SM, Antonarakis ES, Hwang J, Drake JM.   +12 more
europepmc   +1 more source

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Science, 2017
Sheng-Yu Ku, S. Rosario, Yanqing Wang, P. Mu, M. Seshadri, Zachary W. Goodrich, Maxwell M. Goodrich, David P. Labbé, E. C. Gomez, Jian-mei Wang, Henry W. Long, Bo Xu, Myles A. Brown, M. Loda, C. Sawyers, L. Ellis, D. Goodrich   +16 more
semanticscholar   +1 more source

Prostate Cancer [PDF]

Journal of Urology, 1974
openaire   +3 more sources

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Diagnostic Value of FPSAD and PI-RADS v2.1 for Clinically Significant Prostate Cancer in Patients with tPSA Levels of 4-10 ng/mL. [PDF]

Cancer Manag Res
Guo W, Tan P, He Y, Yi X.
europepmc   +1 more source

A PROSTATIC ANNULAR CONSTRICTING LESION OF THE RECTUM

, 1955
William C. Baum, Robert E. McClellan
openalex   +2 more sources

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Management and Treatment of Benign Prostatic Hyperplasia Symptoms: Current Insights. [PDF]

Res Rep Urol
Zekraoui O, Bhojani N, Zorn KC, Elterman D, Chughtai B.   +4 more
europepmc   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source