Results 131 to 140 of about 470,180 (259)

Prostate cancer associated 3 (PCA3) is a potential indicator of the pathological grades of prostate cancer. [PDF]

Discov Oncol
Guo Y, Chen W, Zhu J, Wang X, Ding Y, Duan L, Mai Y, Bai Y, Niu Y, Zhao Y.   +9 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Genetic Polymorphisms and Antioxidant Reactions in Prostate Cancer. [PDF]

Int J Mol Sci
Kamiński P, Dróżdż-Afelt J, Gorzelańczyk EJ, Baszyński J, Tkaczenko H, Hromada M, Nuszkiewicz J, Woźniak A, Kurhaluk N.   +8 more
europepmc   +1 more source

Prostate Cancer

Oncology Times, 2004
openaire   +2 more sources

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Oligometastatic Prostate Cancer: Clues from an N-of-1. [PDF]

J Clin Med
Kirschenbaum A, Verma P, Cheung P, Yao S, Drummond C, Tipi I, Yao A, Levine AC.   +7 more
europepmc   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Cancer of the Prostate [PDF]

Postgraduate Medical Journal, 1958
openaire   +2 more sources

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

IDH1 Mutations Are Associated with Favorable Outcomes in Prostate Cancer. [PDF]

Eur Urol
Cavka L, Nandakumar S, Wu Q, Mehta NJ, Ozay ZI, Begum A, Kundra R, Shannon E, Nazari SS, Evans MG, Smith N, Elliott A, Samueli B, Fine SW, Chen JF, Kantoff PW, Velho PI, Wang H, Sanin DE, Van Allen EM, Agarwal N, Abida W, Lotan TL, Schultz N, Antonarakis ES, Sena LA.   +25 more
europepmc   +1 more source