Results 181 to 190 of about 5,996,360 (285)

Prostatic cancer

Kidney International, 1993
openaire   +2 more sources

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

New England Journal of Medicine, 2017
N. James, J. D. de Bono, M. Spears, N. Clarke, M. Mason, D. Dearnaley, A. Ritchie, C. Amos, C. Gilson, Robert J. Jones, D. Matheson, R. Millman, G. Attard, S. Chowdhury, W. Cross, S. Gillessen, C. Parker, M. Russell, D. Berthold, C. Brawley, F. Adab, San Aung, A. Birtle, J. Bowen, S. Brock, P. Chakraborti, C. Ferguson, J. Gale, E. Gray, M. Hingorani, P. Hoskin, J. Lester, Z. Malik, F. McKinna, N. McPhail, J. Money-Kyrle, J. O’Sullivan, O. Parikh, A. Protheroe, A. Robinson, N. Srihari, Carys W Thomas, J. Wagstaff, J. Wylie, A. Zarkar, M. Parmar, M. Sydes   +46 more
semanticscholar   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Metastatic Prostate Cancer Masquerading as Locally Advanced Breast Cancer. [PDF]

Clin Case Rep
Howard T, Monna MG, Zhu J, Teh J, Lee ST, Chew GL.   +5 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Evolving strategies in prostate cancer: Emerging approaches and unmet needs from the Bridging the Gaps in Prostate Cancer expert panel. [PDF]

Cancer
McKay RR, Maughan BL, Morgans AK, Shore ND, Yu EY, Madan RA, Berchuck JE, Carthon BC, Finkelstein SE, Gomella L, Gorin MA, Hahn AW, Loeb S, Narayan VK, Petrylak DP, Ryan CJ, Tawagi K, Tran PT, Dorff T.   +18 more
europepmc   +1 more source

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Metastatic Prostate Cancer Presenting as Fatigue in an Older Adult. [PDF]

Clin Case Rep
Tidball AR, Harlow EN.
europepmc   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source