Results 261 to 270 of about 1,125,014 (336)

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

The molecular pathogenesis of SOX2 in prostate cancer. [PDF]

Discov Oncol
Liu S, Yu H, Zhao Z.
europepmc   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Immunomodulation and Immunotherapy for Patients with Prostate Cancer: An Up-to-Date Review. [PDF]

Biomedicines
Murray NP.
europepmc   +1 more source

Rectal examination for early detection of prostatic cancer.

, 1983
YOHJI KATSUOKA
openalex   +2 more sources

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Prostate Cancer: genetics in practice now and in the future. [PDF]

Hered Cancer Clin Pract
McHugh J, Bancroft E, Kote-Jarai Z, Eeles R.   +3 more
europepmc   +1 more source

PROGNOSTIC EVALUATION OF PROSTATIC CANCER BY GLEASON'S HISTOPATHOLOGIC GRADING AND TISSUE DHT LEVEL

, 1988
Yoshiteru Kohama, Masaaki Morioka, Yoshihiro Kamei, Yukio Yamamoto, Yasukazu Sen, Yukitoshi Fujita, Hiroshi Sonobe   +6 more
openalex   +2 more sources

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Immunotherapy in Prostate Cancer: From a "Cold" Tumor to a "Hot" Prospect. [PDF]

Cancers (Basel)
Kwon WA, Joung JY.
europepmc   +1 more source