Results 281 to 290 of about 1,172,272 (355)

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

The utility of next-generation sequencing in metastatic prostate cancer FNA biopsies. [PDF]

Cancer Cytopathol
Sirohi D, Cornelia Ding CK, Stohr BA, Balassanian R, Vohra P, Aggarwal R, Chan E, Greenland NY.   +7 more
europepmc   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Association of marginalization and PSMA-PET in prostate cancer An analysis of the Ontario PSMA-PET Registry for Recurrent Prostate Cancer. [PDF]

Can Urol Assoc J
Tan VS, Metser U, Rashid M, Langer DL, MacCrostie P, Green B, Mak V, Kulkarni GS, Shayegan B, Pautler S, Lavallée LT, Finelli A, Klotz L, Hagerty M, Bauman G.   +14 more
europepmc   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

Systems biology successes and areas for opportunity in prostate cancer. [PDF]

Endocr Relat Cancer
Orman MV, Graham LS, Cramer SD, Costello JC.   +3 more
europepmc   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

Overdiagnosis and Overtreatment in Prostate Cancer. [PDF]

Diseases
Dushimova Z, Iztleuov Y, Chingayeva G, Shepetov A, Mustapayeva N, Shatkovskaya O, Pashimov M, Saliev T.   +7 more
europepmc   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, EarlyView.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source