Results 41 to 50 of about 3,759,163 (248)

Variation in harms and benefits of prostate‐specific antigen screening for prostate cancer by socio‐clinical risk factors: A rapid review

BJUI Compass
Objective To analyse the latest evidence on the relative harms and benefits of screening and diagnostic pathways with close examination of (i) men aged 50 years or older, (ii) men whose ethnicity places them at higher risk and (iii) men with a family ...
Abel Tesfai, Natalia Norori, Thomas A. Harding, Yui Hang Wong, Matthew David Hobbs   +4 more
doaj   +1 more source

SETD2, GIGYF2, FGFR3, BCR, KMT2C, and TSC2 as candidate genes for differentiating multilocular cystic renal neoplasm of low malignant potential from clear cell renal cell carcinoma with cystic change [PDF]

Investigative and Clinical Urology, 2019
Purpose: Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) and clear cell renal cell carcinoma with cystic change (MCRCC) have different prognoses despite similar histologic characteristics.
Sung Han Kim, Weon Seo Park, Jinsoo Chung   +2 more
doaj   +1 more source

Increasing the attractiveness of surgical disciplines for students: Implications of a robot-assisted hands-on training course for medical education

Frontiers in Surgery, 2022
BackgroundStructured implementation of robot-assisted surgery in the field of medical education is lacking. We assessed students' interest in robot-assisted surgery and tested if the implementation of a hands-on robotic course into the curriculum could ...
Jonas Ekrutt, Sami-Ramzi Leyh-Bannurah, Sophie Knipper, Frederik Schramm, Burkhard Beyer, Tobias Maurer, Tobias Maurer, Markus Graefen, Lars Budäus   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine [PDF]

, 2010
<p><b>Background:</b> Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing ...
Page Elizabeth, Donaldson, A., Mitra, A, Stapleton, A., Donaldson, Alan, Douglas, F., Douglas, F, Whitaker Hayley C., Fiona Douglas, Leongamornlert, D., Catherine Mercer, null null, Izatt Louise, Tymrakiewicz, M., Lilja, H, Jhavar, S, Whitaker, Hayley C., Vickers, A., Anne George, Walker, L, Warren, Anne Y., Stapleton, A, David E. Neal, Elizabeth Page, Izatt, Louise, Easton, D., Virginia Clowes, Hans Lilja, Leongamornlert, D, Warren Anne Y., Neal David E., Anne Y. Warren, Lindeman, Geoffrey J., Alan Donaldson, Cooper, C., IMPACT Study Steering Committee, Tucker, Kathy, Evans, DG, Bancroft, E., Whitaker, HC, Blanco, I, Stapleton, Alan, Eeles, Rosalind, Easton, Douglas, Hodgson Shirley, Neal, David E., Blanco, I., Jimmy Lam, Lindeman, G.J., Leongamornlert Daniel, Geoffrey J. Lindeman, Tobias, E.S., Mercer, C, Leongamornlert, Daniel, Saunders, Edward, Lam, Jimmy, Izatt, L, Kirk, J, Clowes, V., Hodgson, Shirley, Douglas Easton, Daniel Leongamornlert, Rubinstein, W.S., Shirley Hodgson, David E Neal, Lisa Walker, Mitchell, G., Kirk, Judy, Ignacio Blanco, Donaldson, A, George, Anne, Eeles, R., D Gareth Evans, Neal, DE, Elizabeth Bancroft, Dorkins, H, Ross-Adams, Helen, Evans, D. Gareth; id_orcid, Bancroft, E, Gillian Mitchell, Rubinstein, WS, Bancroft Elizabeth, Donaldson Alan, Lam, J., Lindeman, GJ, Page, Elizabeth, Ross-Adams, H., Male, A, Kote-Jarai Zsofia, Bancroft, Elizabeth K., George, A., Saunders, E, Tucker Kathy, Saunders, E., Cooper Colin, Huw Dorkins, UK GPCS Collaborators, Tymrakiewicz, M, Walker Lisa, Kote-Jarai, Z., Evans, D. Gareth, Burge, Johanna, Walker, Lisa, Lilja Hans, Clowes Virginia, Rubinstein Wendy S., Evans D. Gareth, Mercer, C., Eeles Rosalind, Burge, J, Page, E, Bancroft, Elizabeth, Ross-Adams, H, Judy Kirk, Hayley C. Whitaker, Dorkins, H., Warren, A.Y., Page, E., Lilja, Hans, Anne Y Warren, Colin Cooper, Rosalind Eeles, D. Gareth Evans, Burge Johanna, Dorkins, Huw, Mitchell Gillian, Lindeman Geoffrey J., Evans, D.G., Anita Mitra, Wendy S Rubinstein, Mercer Catherine, Eeles, R, Geoffrey J Lindeman, Lilja, H., Ross-Adams Helen, Stapleton Alan, Rubinstein, Wendy S., Mitra, A., Hodgson, S., Neal, D.E., Easton, D, Jhavar, S., Alan Stapleton, Mitchell, G, Male, Alison, George Anne, Cooper, C, Wendy S. Rubinstein, Edward Saunders, Jhavar Sameer, Hodgson, S, Cooper, Colin, Helen Ross-Adams, Louise Izatt, Kote-Jarai, Zsofia, Blanco Guillermo, Ignacio, Tucker, K., Male Alison, Malgorzata Tymrakiewicz, Kote-Jarai, Z, Blanco, Ignacio, Saunders, Edward J., Evans, D. G., Johanna Burge, Tucker, K, Saunders Edward, Dorkins Huw, Tymrakiewicz, Malgorzata, Kirk, J., Mitra, Anita, Jhavar, Sameer, Blanco Ignacio, Douglas, Fiona, Mitchell, Gillian, Whitaker, H.C., Male, A., IMPACT Study Collaborators, Alison Male, Sameer Jhavar, Clowes, Virginia, Hayley C Whitaker, Tymrakiewicz Malgorzata, Warren, AY, Kathy Tucker, Zsofia Kote-Jarai, Mitra Anita, Kirk Judy, Mercer, Catherine, Lam, J, George, A, Douglas Fiona, Burge, J., Easton Douglas, Clowes, V, Lam Jimmy, Walker, L., Whitaker, H. C., Izatt, L.   +197 more
core   +1 more source

The impact of pre‐biopsy MRI and additional testing on prostate cancer screening outcomes: A rapid review

BJUI Compass
Objective This work aims to examine the latest evidence on the impact of pre‐biopsy MRI, in addition to prostate‐specific antigen (PSA) testing, on health outcomes and quality of life.
Abel Tesfai, Natalia Norori, Thomas A. Harding, Yui Hang Wong, Matthew David Hobbs   +4 more
doaj   +1 more source

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine

Genome Medicine, 2023
Background Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include evolution as ...
Anssi Nurminen, Serafiina Jaatinen, Sinja Taavitsainen, Gunilla Högnäs, Tom Lesluyes, Naser Ansari-Pour, Teemu Tolonen, Kerstin Haase, Antti Koskenalho, Matti Kankainen, Juho Jasu, Hanna Rauhala, Jenni Kesäniemi, Tiia Nikupaavola, Paula Kujala, Irina Rinta-Kiikka, Jarno Riikonen, Antti Kaipia, Teemu Murtola, Teuvo L. Tammela, Tapio Visakorpi, Matti Nykter, David C. Wedge, Peter Van Loo, G. Steven Bova   +24 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Survival prognoses of Heng intermediate-risk patients with metastatic renal cell carcinoma treated with immunotherapy or targeted therapy: A real-world, single-center retrospective study [PDF]

Investigative and Clinical Urology, 2020
Purpose: This study aimed to compare progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS) in Heng intermediate-risk patients with metastatic renal cell carcinoma (mRCC) treated with first-line immunotherapy (IT) or ...
Sung Han Kim , Dong-Eun Lee , Jae Young Joung , Ho Kyung Seo , Kang Hyun Lee , Jinsoo Chung   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source