Results 81 to 90 of about 3,759,163 (248)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Prostate Cancer Information Needs of Australian Gay and Bisexual Men

, 2015
In spite of the vast amount of research into prostate cancer, sexual orientation is not a piece of information that is routinely collected in cancer registries, nor is it usually asked of men who participated in prostate cancer research studies, which ...
Mitchell, Anne, Dowsett, Gary W, Wong, W K Tim, O'Keefe, David, Duncan, Duane, Lowe, Anthony   +5 more
core  

Survival outcomes in men with a positive family history of prostate cancer: a registry based study

BMC Cancer, 2020
Background To investigate the correlation between family history of prostate cancer (PCa) and survival (overall and cancer specific) in patients undergoing treatment for PCa.
Mann Ang, Martin Borg, Michael E. O’Callaghan, for the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC)   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Highlights of prostate cancer research in Ireland

, 2010
Summary document highlighting prostate cancer research in Ireland.The publication of this report was supported by an educational grant from ...
Prostate Cancer Research Consortium
core  

Finasteride Upregulates Expression of Androgen Receptor in Hyperplastic Prostate and Lncap Cells: Implications for Chemoprevention of Prostate Cancer

, 2012
BACKGROUND: Although finasteride is recognized for its role as a chemopreventive agent for prostate cancer, higher grades of malignancy have been reported.
謝汝敦;陳世乾;余宏政;張宏江, HSIEH, JU-TON;CHEN, SHYH-CHYAN;YU, HONG-JENG;CHANG, HONG-CHIANG   +1 more
core   +1 more source

Survival of patients receiving systematic therapy for metachronous or synchronous metastatic renal cell carcinoma: a retrospective analysis

BMC Cancer, 2019
Background The differences in progression-free survival (PFS) and cancer-specific survival (CSS) of metastatic renal cell carcinoma (mRCC) patients according to treatment, type of metastasis, and Heng criteria risk are unclear. In this study, we compared
Sung Han Kim, Dong-eun Lee, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Edwards, J., Bartlett, J.M.S.
core   +1 more source

Transrectal ultrasound–cystogram versus X-ray–cystogram versus no cystogram: high volume retrospective study

Prostate International
Background: A comparison among X-ray-cystograms (CGs), TRUS-CGs, and no CG to determine the required indwelling time of urinary catheters after radical prostatectomy (RP).
Helene Schuetz, Lukas Hohenhorst, Yamini Nagaraj, Markus Graefen, Pierre Tennstedt, Georg Salomon, Randi M. Pose   +6 more
doaj   +1 more source