Results 101 to 110 of about 1,084,057 (356)
Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng +12 more
wiley +1 more source
Distinct expression patterns of ER alpha and ER beta in normal human mammary gland [PDF]
, 2002 AIM: Two oestrogen receptors (ERs) have been identified to date—the “classic” ERa and the more recently described ERb. Although much is known about ERa at the mRNA and protein levels, our knowledge of the expression and distribution of ERb protein is ...
Burdall, S.E. +3 more
core
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Advanced Science, EarlyView.Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
Frontiers in Oncology, 2019 Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
M. Rice, S. Malhotra, Tanya Stoyanova
semanticscholar +1 more source
GPU-based ultra-fast direct aperture optimization for online adaptive radiation therapy
, 2010 Online adaptive radiation therapy (ART) has great promise to significantly reduce normal tissue toxicity and/or improve tumor control through real-time treatment adaptations based on the current patient anatomy.
Bazaraa M +21 more
core +1 more source
Advanced Science, EarlyView.This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li +12 more
wiley +1 more source
LOCATION OF PROSTATE GLAND IN RELATION TO AGE IN CLINICALLY HEALTHY INTACT DOGS [PDF]
Journal of Veterinary and Animal Sciences, 2018 The location of prostate gland in clinically healthy male dogs of different age groups was assessed by digital rectal palpation. and was predominantly intra-pelvic (87.5%) in dogs aged less than 2 yrs. Among the dogs above 8 yrs. of age, only 25 per cent
B. Bibin Becha +3 more
doaj
Journal of the American Medical Association, 1887 The importance to the genito-urinary surgeon of a due appreciation of the pathological changes underlying a sound system of therapeutics, of that portion of the urinary canal called the posterior or prostatic urethra, and surrounded by that composite body called the prostate gland, must be my apology for entering into a consideration of its minute ...
openaire +1 more source
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Androgens and prostate disease
Asian Journal of Andrology, 2014 A growing body of literature has established the anabolic benefi ts of testosterone (T) therapy in hypogonadal men. However, there remains a paucity of data regarding the risks of exogenous androgen use in older men and the potential for adverse effects ...
Lori A Cooper, Stephanie T Page
doaj +1 more source