Results 111 to 120 of about 1,084,057 (356)
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer
Nature, 2019 Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the normal development of several endoderm-derived organs, including the prostate gland1,2.
A. Parolia +16 more
semanticscholar +1 more source
Advanced Science, EarlyView.TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han +10 more
wiley +1 more source
Analysis of oncological outcomes of whole-gland therapy with high-intensity focused ultrasound for localized prostate cancer in clinical and technical aspects: a retrospective consecutive case-series analysis with a median 5-year follow-up [PDF]
, 2021 Sunao Shoji +13 more
openalex +1 more source
Anatomy-Aware Measurement of Segmentation Accuracy
, 2016 Quantifying the accuracy of segmentation and manual delineation of organs, tissue types and tumors in medical images is a necessary measurement that suffers from multiple problems.
Othman, Ahmed A., Tizhoosh, Hamid R.
core +1 more source
Advanced Science, EarlyView.In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo +19 more
wiley +1 more source
Physics and Imaging in Radiation OncologyFocal boost to intra-prostatic lesions (IPLs) in radiotherapy could enhance treatment efficacy. Brachytherapy (BT), delivering highly conformal dose with sharp dose gradients emerges as a potentially optimal approach for precise dose escalation to IPLs ...
Joel Poder +4 more
doaj +1 more source
The Influence of Transrectal Multifocal Prostate Biopsy Under Ultrasound Control on the Degree of Infravesical Obstruction in Different Groups of Patients [PDF]
, 2016 . Prostate cancer - is a Malignant neoplasm arising from prostatic epithelium. [1] It is well known, that prostate cancer is the most common cancer in men population.
Avakyan, A. (Armen) +2 more
core
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
Advanced Science, EarlyView.This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan +21 more
wiley +1 more source
Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source