Results 231 to 240 of about 212,555 (306)

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

Orthotopic Transcatheter Tricuspid Valve Replacement After Heterotopic Caval Valve Failure. [PDF]

JACC Case Rep
Biroli M, Lu C, Ferrari C, Fazzari F, Mangieri A, De Marco F.   +5 more
europepmc   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

Staged Full-Arch Rehabilitation With Tilted and Pterygoid Implants: A Pragmatic Hybrid Analog-Digital Workflow With 2-Year Follow-Up. [PDF]

Case Rep Dent
Liborio F, Sciarra FM, Di Vita E, Nigliaccio S, Fontana DA, Messina P, Cumbo EM, Scardina GA.   +7 more
europepmc   +1 more source

Hydrogel‐Based Bioelectronics: From Therapy and Sensing to Neuromorphic Computation

FlexTech, EarlyView.
This review establishes a material–conduction–property–application framework connecting hydrogel chemistry and charge transport with therapy, sensing, closed‐loop feedback, and neuromorphic computation. ABSTRACT Bioelectronics establish bidirectional communication between living systems and electronic devices, providing an enabling platform for ...
Jianlong Hong, Jiaqi Lu, Yijun Hao, Ning Ren, Shuhan He, Haobo Qi, Jingfeng Xu, Chengkuo Lee   +7 more
wiley   +1 more source

3D-printed patient-specific instrumentation significantly improves the accuracy of prosthesis alignment in unicompartmental knee arthroplasty: a retrospective study. [PDF]

3D Print Med
Zhang K, Zhang J, Gao S, Li Z, Shen N, Meng X, Sun P.   +6 more
europepmc   +1 more source

Oral rehabilitation of patients with cancer: challenges following surgical resection. [PDF]

Support Care Cancer
da Costa Rodrigues Neto S, Moreira TCA, Pereira MMA, Viana MOS.   +3 more
europepmc   +1 more source

A set of complications during percutaneous valve-in-valve replacement: Coronary occlusion, device migration, surgical rescue, and mechanical support. [PDF]

JTCVS Struct Endovasc
Relvas Novo C, Campos M, Gomes B, Lima A, Cardoso J, Rodrigues A, Neves P.   +6 more
europepmc   +1 more source