Results 121 to 130 of about 86,843 (248)
Poultry feeding in organic farming [PDF]
, 2015 This technical guide synthesizes knowledge available about: - The physiological mechanisms of poultry, - Nutritional requirements and recommended intakes, - The feeding behaviour of organic poultry, - The nutritional value of raw materials, - The
Bordeaux, Célia, Roinsard, Antoine
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Production de cérérales d'hiver et de printemps dans les Maritimes [PDF]
, 2010 Des producteurs d’aliments biologiques souhaitent étendre la rotation de leurs cultures en ajoutant les céréales d’hiver à leur production. Les céréales d’hiver peuvent offrir bien des avantages : elles peuvent servir de couverture de sol durant les mois
Hammermeister, Andy +2 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Apprêtement des antigènes présentés par les molécules de classe I du CMH [PDF]
, 2006 Les défenses immunitaires de l’organisme vis-à-vis des agents pathogènes et des cellules malignes reposent en grande partie sur la surveillance par les lymphocytes T cytotoxiques.
Endert, Peter van
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Enrichissement en protéines du tourteau de coprah : sélection de champignons filamenteux en FMS [PDF]
, 1994 Les résultats ont montré que 11 souches sur 51 testées peuvent être retenues. Elles appartiennent aux espèces Aspergilus sp., Aspergillus niger, Penicillium italicum, Penicillium sp., et Penicillium roquefortii.
Diez, M. +6 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source