Results 51 to 60 of about 6,469,838 (241)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Plantes transgèniques i agricultura: present i futur [PDF]
, 2011 planta transgènica, resistència a plagues, tolerància a estrès, resistència a Des de la seva comercialització a mitjan anys noranta, el cultiu de varietats transgèniques ha crescut de manera continuada fins avui dia.
Boronat i Margosa, Albert
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Identificada una molècula que facilitaria l'acció dels antifúngics [PDF]
, 2014 A causa de la similitud entre certes proteïnes dels fongs patògens i d'altres humanes, els medicaments antifúngics actuals solen estar dirigits contra característiques que estan presents en els fongs patògens i absents en els éssers humans.
Casamayor Gracia, Antonio
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Com s'ha d'abordar l'anàlisi d'al·lèrgens i la interpretació dels seus resultats? [PDF]
, 2008 Aquest article recull principalment la presentació que amb el mateix títol es va realitzar a l'Institut Químic de Sarrià de Barcelona, en el marc del XI Food Studies: Focus on Food Allergens, el 22 de novembre de 2007. Es fa una revisió de les tècniques
González Valdelièvre, Pascal
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Sistema de control per a la producció microbiana de proteïnes [PDF]
, 2006 El Departament d'Enginyeria Química de la UAB treballa en el desenvolupament de noves tecnologies per millorar, tant qualitativament com quantitativa, la producció de proteïnes recombinants -obtingudes mitjançant modificació genètica d'un organisme-. Ara
López Santín, Josep +2 more
core +1 more source