Results 131 to 140 of about 1,749,266 (388)

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

Nature Communications, 2016
The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious threat to the global public health. The viral protease that processes viral polyproteins during infection appears as an attractive drug target.
W. W. Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Y. R. Loh, Yaw Bia Tan, Elizabeth Yihui Ng, J. Lescar, C. Kang, D. Luo   +9 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni

Gut Pathogens, 2011
Background Acute gastroenteritis caused by the food-borne pathogen Campylobacter jejuni is associated with attachment of bacteria to the intestinal epithelium and subsequent invasion of epithelial cells. In C.
Bæk Kristoffer T, Vegge Christina S, Brøndsted Lone   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

proteases

, 2014
Citation: 'proteases' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.P04894 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Janice Pero, Alan Sloma
  +5 more sources

OPTIMASI JENIS DAN KADAR SUMBER NITROGEN SERTA pH MEDIUM UNTUK PRODUKSI PROTEASE DARI ISOLAT HTcUM6.2.2 DARI TAUCO SURABAYA

Jurnal Kimia Riset, 2017
Abstrak Penelitian ini bertujuan untuk  mengetahui sumber nitrogen, kadar sumber nitrogen dan pH optimum untuk produksi protease isolat HTcUM6.2.2. Penelitian ini merupakan penelitian eksperimental laboratoris menggunakan Rancangan Acak Lengkap (RAL ...
Monika Rahayu, Evi Susanti
doaj   +1 more source

A Study of Archiving Strategies in Multi-Objective PSO for Molecular Docking [PDF]

, 2016
Molecular docking is a complex optimization problem aimed at predicting the position of a ligand molecule in the active site of a receptor with the lowest binding energy. This problem can be formulated as a bi-objective optimization problem by minimizing
A Sandoval-Perez, AP Norgan, CA Coello, DJ Sheskin, E López-Camacho, E López-Camacho, E Zitzler, E Zitzler, GM Morris, J Gu, JJ Durillo, K Deb, MJ García-Godoy, MR Sierra, Q Zhang, S Janson   +15 more
core   +1 more source

HIV protease inhibitors: a review of molecular selectivity and toxicity

HIV/AIDS, 2015
Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages.
Zhengtong Lv, Y. Chu, Yong Wang
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transport of proteins into mitochondria [PDF]

, 1985
Translocational intermediates of precursor proteins of ATPase F1β subunit and cytochrome c1 across mitochondrial membranes were analyzed using two different approaches, transport at low temperature and transport after binding of precursor proteins to ...
Neupert, Walter, Schleyer, Manfred
core   +1 more source