Results 151 to 160 of about 1,607,552 (384)

HIV-1 Protease Inhibitors From Marine Brown Alga: A Literature Review [PDF]

, 2017
The human immunodeficiency virus type 1 (HIV-1) causes an infectious disease that if left untreated can progress to acquired immunodeficiency syndrome (AIDS) and be fatal.
Nunez Aguilar, Eric
core   +1 more source

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell, 2020
M. Hoffmann, Hannah Kleine-Weber, S. Schroeder, Nadine Krüger, T. Herrler, Sandra Erichsen, T. Schiergens, G. Herrler, N. Wu, A. Nitsche, M. Müller, C. Drosten, S. Pöhlmann   +12 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Lead contamination alters enzyme activities and microbial composition in the rhizosphere soil of the hyperaccumulator Pogonatherum crinitum

Ecotoxicology and Environmental Safety, 2021
Pogonatherum crinitum is a promising lead (Pb) hyperaccumulator; however, the effects of Pb contamination on P. crinitum rhizosphere soil enzymatic activities and microbial composition remain largely unexplored.
Xiao-long Hou, Hang Han, Mulualem Tigabu, Qi-yan Li, Zong-xun Li, Chen-lu Zhu, Si-qi Huang, Li-ping Cai, Ai-qin Liu   +8 more
doaj  

Response Surface Methodology Optimization of an Acidic Protease Produced by Penicillium bilaiae Isolate TDPEF30, a Newly Recovered Endophytic Fungus from Healthy Roots of Date Palm Trees (Phoenix dactylifera L.)

Microorganisms, 2019
To explore proteolytic activity of endophytic fungi inhabiting date palm roots, a Penicillium bilaiae isolate, displaying the highest level of protease production, has been recovered.
Fedia Ben Mefteh, Fakher Frikha, Amal Daoud, Ali Chenari Bouket, Lenka Luptakova, Faizah N. Alenezi, Bader S. Al-Anzi, Tomasz Oszako, Neji Gharsallah, Lassaad Belbahri   +9 more
doaj   +1 more source

A neutrophil-dependent pathway for the generation of a neutral peptide mediator: partial characterization of components and control by alpha-1-antitrypsin. [PDF]

, 1974
A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an alpha-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of
Austen, KF, Goetzl, EJ, Wintroub, BU
core  

Crucial stages of protein folding through a solvable model: predicting target sites for enzyme-inhibiting drugs

, 2002
An exactly solvable model based on the topology of a protein native state is applied to identify bottlenecks and key-sites for the folding of HIV-1 Protease. The predicted sites are found to correlate well with clinical data on resistance to FDA-approved
Ala, Alessandro Flammini, Alm, Amos Maritan, Atilgan, Bahar, Bahar, Baker, Camacho, Camacho, Cecconi, Chan, Chiti, Clementi, Condra, Cristian Micheletti, Debe, Fabio Cecconi, Fersht, Flory, Galzitskaya, Go, Hoang, Jackson, Jacobsen, Kaya, Kaya, Keskin, Kloczkowski, Lazaridis, Maiorov, Maritan, Markowitz, Martinez, Micheletti, Micheletti, Micheletti, Miyazawa, Molla, Patick, Plaxco, Reddy, Riddle, Sali, Seno, Settanni, Sippl, Tisdale, Wolynes   +48 more
core   +2 more sources

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

Journal of Experimental Medicine, 1996
Bcl-2 belongs to a family of apoptosis-regulatory proteins which incorporate into the outer mitochondrial as well as nuclear membranes. The mechanism by which the proto-oncogene product Bcl-2 inhibits apoptosis is thus far elusive.
S. Susin, N. Zamzami, M. Castedo, Tamara Hirsch, P. Marchetti, A. Macho, E. Daugas, M. Geuskens, G. Kroemer   +8 more
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

A Study of the Action of Purified Thyroid Protease on l31I-Labelled Thyroglobulin [PDF]

, 1954
Mary T. McQuillan, P. G. Stanley, VM Trikojus   +2 more
openalex   +1 more source