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Experientia, 1996
The interleukin-1 beta-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide
Sten Orrenius +2 more
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The interleukin-1 beta-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide
Sten Orrenius +2 more
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Proteases and Protease Inhibitors in Neoplasia
1974Although proteases in tumours have been studied for many years [1], their role is far from clear. From a number of comparative studies (summarized in Table 1), however, it can be safely concluded that increased proteolytic activity is often associated with tumours.
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Characterization of proteases and protease inhibitors in the rat stomach
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1997Previously our laboratory reported increased activity of the thiol proteinase cathepsin B in gastric juice after ethanol-induced mucosal injury. In this study we measured proteinase activity (PA) and proteinase inhibitory activity (PIA) with the general substrates hemoglobin, azocasein, and bovine serum albumin (BSA) at optimal pH (2.0, 5.6, and 7.4 ...
B. R. Johnson +3 more
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Chemical Reviews, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
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AbstractFor Abstract see ChemInform Abstract in Full Text.
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Proteases and Protease Inhibitors in Male Reproduction
2017From the development of the spermatozoa within the seminiferous tubule of testis to the fertilization events that occur in female reproductive tract, all the reproductive processes in mammals are regulated by a highly orchestrated and integrative mechanism. Several proteases and their protease inhibitors form an important part of this mechanism. So far,
S.C. Roy, Vijayasaraswathy S. Gurupriya
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2012
Publisher Summary This chapter focuses on non-digestive proteases, which have many diverse roles in insect biology. Proteases (peptidases) are enzymes that hydrolyze peptide bonds in proteins. These proteases often function in cascade pathways, in which one protease activates the zymogen form of another protease, leading to amplification of an initial
Michael R. Kanost, Rollie J. Clem
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Publisher Summary This chapter focuses on non-digestive proteases, which have many diverse roles in insect biology. Proteases (peptidases) are enzymes that hydrolyze peptide bonds in proteins. These proteases often function in cascade pathways, in which one protease activates the zymogen form of another protease, leading to amplification of an initial
Michael R. Kanost, Rollie J. Clem
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Proteases and Protease Inhibitors in Tissue Repair
2000Healing of wounds in the peritoneum and the skin may seem to be quite different, but at the molecular level they share many common aspects. For example, both peritoneal and skin wound healing involve inflammation, chemotactic migration, mitosis and differentiation of wound cells, and synthesis or remodeling of extracellular matrix.
Gregory S. Schultz, William C. Parks
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2004
Publisher Summary This chapter focuses on the structural chemistry and the biological aspects of S2P protease. S2P is a highly hydrophobic metalloprotease that cleaves its substrates within membrane-spanning domains. It was identified as a component of the processing machinery necessary for the end-product feedback regulation of lipid biosynthesis in ...
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Publisher Summary This chapter focuses on the structural chemistry and the biological aspects of S2P protease. S2P is a highly hydrophobic metalloprotease that cleaves its substrates within membrane-spanning domains. It was identified as a component of the processing machinery necessary for the end-product feedback regulation of lipid biosynthesis in ...
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