Results 341 to 350 of about 1,749,266 (388)
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Proteases and protease inhibitors in infectious diseases
Medicinal Research Reviews, 2017AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro +3 more
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Current Opinion in Gastroenterology, 2023
Purpose of review Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic activity (PA) in the intestinal tract, and how dysregulation of intestinal ...
Sameer, Rao, Madhusudan, Grover
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Purpose of review Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic activity (PA) in the intestinal tract, and how dysregulation of intestinal ...
Sameer, Rao, Madhusudan, Grover
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Proteases, proteases and proteases for presentation
Nature Immunology, 2003Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
Herberts, Carla +2 more
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Parasitology Today, 1988
While studies of schistosome antigens have proceeded rapidly over the past ten years, studies of schistosome enzymes have also been increasing apace. Now the two `lines' of research are coming together. Parasites such as schistosomes hardly present antigens merely to stimulate a host immune response, so it is not surprising that many antigens turn out ...
J H, McKerrow, M J, Doenhoff
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While studies of schistosome antigens have proceeded rapidly over the past ten years, studies of schistosome enzymes have also been increasing apace. Now the two `lines' of research are coming together. Parasites such as schistosomes hardly present antigens merely to stimulate a host immune response, so it is not surprising that many antigens turn out ...
J H, McKerrow, M J, Doenhoff
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Proteases, protease inhibitors and radiation carcinogenesis
International Journal of Radiation Biology, 2021The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
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Current Opinion in Biotechnology, 2004
Over the past 20 years, the development of subtilisins as typical detergent proteases has employed all the tools of enzyme technology, resulting in a constant flow of new and improved enzymes. The number of molecules identified and characterized, however, is in clear opposition to the number of molecules that are entering the market.
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Over the past 20 years, the development of subtilisins as typical detergent proteases has employed all the tools of enzyme technology, resulting in a constant flow of new and improved enzymes. The number of molecules identified and characterized, however, is in clear opposition to the number of molecules that are entering the market.
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Chemical Reviews, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
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AbstractFor Abstract see ChemInform Abstract in Full Text.
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Engineering of proteases and protease inhibition
Current Opinion in Biotechnology, 1991Proteases are unquestionably the single most studied class of enzymes and yet many questions still remain about their mechanisms and roles. Protein engineering offers the opportunity to provide some of the answers. In this review, recent advances towards the understanding of stability, mechanism, specificity and regulation of proteases and their ...
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Proteases and Protease Inhibitors in Tumor Progression
1997Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex ...
Y A, DeClerck +5 more
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