Results 71 to 80 of about 1,607,552 (384)

Citrus psorosis virus movement protein contains an aspartic protease required for autocleavage and the formation of tubule-like structures at plasmodesmata [PDF]

, 2018
Plant virus cell-to-cell movement is an essential step in viral infections. This process is facilitated by specific virus-encoded movement proteins (MPs), which manipulate the cell wall channels between neighboring cells known as plasmodesmata (PD ...
Borniego, María Belén, Garcia, Maria Laura, Heinlein, Manfred, Peña, Eduardo José, Robles Luna, Gabriel   +4 more
core   +3 more sources

TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Journal of Virology, 2019
Influenza A viruses (IAV) and influenza B viruses (IBV) cause significant morbidity and mortality during seasonal outbreaks. Cleavage of the viral surface glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and ...
H. Limburg, Anne Harbig, Dorothea Bestle, D. A. Stein, H. Moulton, J. Jaeger, Harshavardhan Janga, Kornelia Hardes, J. Koepke, Leon N. Schulte, A. Koczulla, B. Schmeck, H. Klenk, E. Böttcher-Friebertshäuser   +13 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

PENGARUH KONSENTRASI NaCl TERHADAP AKTIVITAS SPESIFIK PROTEASE EKSTRASELULER DARI BAKTERI HALOFILIK HASIL ISOLASI BITTERN TAMBAK GARAM MADURA [PDF]

, 2009
Protease halofil dapat dimanfaatkan pada proses fermentasi makanan seperti pada pembuatan kecap ikan. Penelitian ini bertujuan untuk memperoleh bakteri halofilik dari isolat bittern tambak garam Madura dan mengisolasi protease halofil ekstraseluler serta
Asy’ari, M., Budiharjo, Rahmad, Ria S., Purbowatiningrum   +2 more
core  

Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis

, 2014
AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and ...
Amanzada, Ahmad, Cameron, Silke, Mechie, Nicolae-Catalin, Röver, Christian   +3 more
core   +1 more source

iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites

Briefings Bioinform., 2018
Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The key to better understanding the mechanisms that control this process is to identify the specific substrates that each protease targets.
Jiangning Song, Yanan Wang, Fuyi Li, T. Akutsu, N. Rawlings, Geoffrey I. Webb, K. Chou   +6 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Microbial Degradation of Amino Acid-Containing Compounds Using the Microcystin-Degrading Bacterial Strain B-9

Marine Drugs, 2018
Strain B-9, which has a 99% similarity to Sphingosinicella microcystinivorans strain Y2, is a Gram-negative bacterium with potential for use in the degradation of microcystin-related compounds and nodularin. We attempted to extend the application area of
Haiyan Jin, Yoshiko Hiraoka, Yurie Okuma, Elisabete Hiromi Hashimoto, Miki Kurita, Andrea Roxanne J. Anas, Hitoshi Uemura, Kiyomi Tsuji, Ken-Ichi Harada   +8 more
doaj   +1 more source

Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]

, 2006
Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ciarán Ó'Fágáin, Collins, Dalton, Deborah M. Ruth, Dowd, Dowd, Fujishima, Gillian McMahon, Haensler, Jakubke, Lozano, Mort, Ménard, Sewald, Stehle, Turk, Zhou   +16 more
core   +1 more source

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Journal of Medicinal Chemistry, 2016
HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection.
Arun K. Ghosh, Heather L. Osswald, Gary Prato   +2 more
semanticscholar   +1 more source