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Nicotine-Inspired, De Novo-Designed SARS-CoV-2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad. [PDF]
J Am Chem SocAtla S +18 more
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Kazal-type serine protease inhibitors from Arabidopsis thaliana and Toxoplasma gondii exhibit antimicrobial activity against plant pathogens. [PDF]
Sci RepSánchez MA +8 more
europepmc +1 more source
Bioassay-Guided Phytochemical Investigation of Vietnamese <i>Vitex rotundifolia</i> Leaves and the Liverwort <i>Ptychanthus striatus</i> as Sources of SARS-CoV-2 Main Protease Inhibitors. [PDF]
MoleculesNguyen HT +10 more
europepmc +1 more source
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Protease Inhibitors in the Clinic
Medicinal Chemistry, 2005This review describes the clinical status (based on available information) of experimental drugs that inhibit enzymes called proteases, or more precisely a sub-class of proteases called peptidases that catalyse the hydrolysis of polypeptide main chain amide bonds.
Abbenante, Giovanni, Fairlie , David P.
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Proteases and protease inhibitors in cancer
Acta Histochemica, 1998The second conference on 'Proteases and protease inhibitors in cancer' was organized by the American Association for Cancer Research (AACR) and Acta Pathologica Microbiologica et Immunologica Scandinavica (APMIS). To understand the role of proteinases and to develop relevant synthetic inhibitors to stop or slow the progression of cancer, an integrated ...
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Medicinal Research Reviews, 2002
AbstractSerine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic bacteria, where they play critical functions related to colonization and evasion of host immune defenses, acquisition of nutrients for growth and proliferation, facilitation of dissemination, or tissue damage during infection. Since all the antibiotics used clinically
SUPURAN, CLAUDIU TRANDAFIR +2 more
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AbstractSerine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic bacteria, where they play critical functions related to colonization and evasion of host immune defenses, acquisition of nutrients for growth and proliferation, facilitation of dissemination, or tissue damage during infection. Since all the antibiotics used clinically
SUPURAN, CLAUDIU TRANDAFIR +2 more
openaire +3 more sources
Biopolymers, 1981
AbstractThere is a general parallelism in the strategy followed in the design of hormonal peptide analogs and protease inhibitors. However, in the latter, one more dimension has been added with the development of mechanism‐based inhibitors, a dimension that is not yet available for hormonal peptides because of the lack of knowledge about receptor ...
M A, Ondetti, D W, Cushman
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AbstractThere is a general parallelism in the strategy followed in the design of hormonal peptide analogs and protease inhibitors. However, in the latter, one more dimension has been added with the development of mechanism‐based inhibitors, a dimension that is not yet available for hormonal peptides because of the lack of knowledge about receptor ...
M A, Ondetti, D W, Cushman
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Protease inhibitor monotherapy
Current Opinion in Infectious Diseases, 2011The present review focuses on recent data about boosted protease inhibitor monotherapy for maintenance of HIV virological suppression.Until recently most of the trials of boosted protease inhibitor monotherapy have studied lopinavir/ritonavir monotherapy.
Ignacio, Pérez-Valero, Jose R, Arribas
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