Results 181 to 190 of about 695,446 (323)

Protease inhibitors

European Journal of Pharmaceutical Sciences, 2000
Andrea Scozzafava, Marc A Ilies, Gheorghe Manole, Claudiu T Supuran   +3 more
  +4 more sources

Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro

, 2012
Jianming Lü, Shaoyu Yan, Saha Jamaluddin, Sarah M. Weakley, Zhengdong Liang, Edward B. Siwak, Qizhi Yao, Changyi Chen   +7 more
openalex   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Recent Advances in Heterocyclic HIV Protease Inhibitors. [PDF]

Int J Mol Sci
Funicello M, Chiummiento L, Santarsiere A, Poggio F, Lupattelli P.   +4 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Is gestational exposure to HIV and protease inhibitors associated with timing of pubertal onset? [PDF]

J Acquir Immune Defic Syndr
Serghides L, Lee J, Jacobson DL, Geffner ME, DiMeglio LA, McFarland EJ, Powis KM, Williams PL, Jao J, Pediatric HIV/AIDS Cohort Study.   +9 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Designing Potent HIV‑1 Protease Inhibitors Using Machine Learning and QSAR Approaches. [PDF]

ACS Omega
Ali S, Dwi Putra I, Chuntakaruk H, Wolschann P, Maitarad P, Rungrotmongkol T, Hannongbua S.   +6 more
europepmc   +1 more source

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir

, 2018
Murugaiah A. M. Subbaiah, Nicholas A. Meanwell, John F. Kadow, Lakshumanan Subramani, Mathiazhagan Annadurai, Thangeswaran Ramar, Salil D. Desai, Sarmistha Halder Sinha, Murali Subramanian, Sandhya Mandlekar, Srikanth Sridhar, Shweta Padmanabhan, Priyadeep Bhutani, Rambabu Arla, Susan M. Jenkins, Mark Krystal, Chunfu Wang, Ramakanth Sarabu   +17 more
openalex   +1 more source

Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes [PDF]

, 2000
В. А. Петров, R. Fagard, P. Lijnen   +2 more
openalex   +1 more source