Results 241 to 250 of about 3,573,509 (380)

Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. [PDF]

Biomolecules
Bakkar M, Khalil S, Bhayekar K, Kushwaha ND, Samarbakhsh A, Dorandish S, Edwards H, Dou QP, Ge Y, Gavande NS.   +9 more
europepmc   +1 more source

Effects of salts, protease digestions, chemical modifications, and heat treatment on the trypsin inhibitory activity of the protease inhibitor from Job's-tears (Coix lacryma-jobi L. var. Ma-yuen Stapf).

, 1989
Ken’ichi Ohtsubo
openalex   +2 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

HIV-1 protease inhibitors and mechanisms of HIV-1's resistance. [PDF]

Glob Health Med
Das D.
europepmc   +1 more source

Protease Inhibitors for Treating or Preventing Coronavirus Infection. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Effects of protease inhibitors on the autolysis and protease activities of Antartic krill.

, 1984
Yukio KAWAMURA, Kimio Nishimura, Teruyoshi Matoba, Daizo Yonezawa   +3 more
openalex   +2 more sources

Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells

Advanced Healthcare Materials, EarlyView.
Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L. Oudejans, Emmanouil Kyrloglou, Marc. C. A. Stuart, Wouter H. Roos, Jan Jacob Schuringa, Anna Salvati   +8 more
wiley   +1 more source

Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors. [PDF]

J Virol
Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, Song Y, Estes MK, Palzkill T, Prasad BVV.   +9 more
europepmc   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors. [PDF]

Front Immunol
Wang J, Li J, Zhou L, Hou H, Zhang K.
europepmc   +1 more source