Results 231 to 240 of about 4,152,860 (338)

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties. [PDF]

ACS Omega
Shinohara K, Kobayakawa T, Tsuji K, Takamatsu Y, Mitsuya H, Tamamura H.   +5 more
europepmc   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Identification of Novel <i>Trypanosoma cruzi</i> Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal Activity. [PDF]

Diseases
Vázquez-Jiménez LK, González-González A, Delgado-Maldonado T, Gómez-Escobedo R, Nogueda-Torres B, Martínez-Vázquez AV, Ortiz-Pérez E, Aguirre-Alvarado C, Alcántara-Farfán V, Cordero-Martínez J, Rodríguez-Páez L, Moreno-Rodriguez A, Rivera G.   +12 more
europepmc   +1 more source

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

Cell, 1996
Marta Muzio, A. Chinnaiyan, F. Kischkel, K. O’Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. Bretz, Mei Zhang, R. Gentz, M. Mann, P. Krammer, M. Peter, V. Dixit   +13 more
semanticscholar   +1 more source

Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells [PDF]

, 2008
Delputte, Peter, Misinzo, Gerald, Nauwynck, Hans   +2 more
core  

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Discovery of benzyl carbamate inhibitors of coronavirus M^pro enzymes from a legacy collection of cysteine protease inhibitors. [PDF]

J Enzyme Inhib Med Chem
Sá Magalhães Serafim M, Kronenberger T, Francisco KR, de Sousa Reis EV, Gonçalves de Oliveira E, Marcelino E Oliveira FK, Serraglio Fortes I, Maciel Fernandes TH, Barbosa da Silva E, Fajtova P, Skinner DE, Syed RO, Lage de Siqueira-Neto J, Poso A, Fernandes Mota BE, Alves Coelho-Dos-Reis JG, Santos Abrahão J, Gonçalves Maltarollo V, O'Donoghue AJ, Caffrey CR.   +19 more
europepmc   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source