Results 211 to 220 of about 1,166,800 (296)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Co-cultivation and Medium Optimization: A Strategy for Discovering Fungal-derived Protease Inhibitors. [PDF]

Chem Biodivers
Mazucato VS, Tonani L, von Zeska Kress MR, Andricopulo AD, Barbosa G, Krogh R, Gomes Ferreira LL, Vieira PC.   +7 more
europepmc   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Gene expression and evolution of Bowman-Birk protease inhibitors in wild and domesticated <i>Vigna</i> (Fabaceae) species. [PDF]

Front Plant Sci
Toini E, Totaro M, Silvestri G, Vertemara J, Zecca G, Panzeri D, Palm ER, Wagensommer RP, Zampella G, Labra M, Grassi F.   +10 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Correction: Discovery of protease inhibitors from bacteria as novel adjuvants for oral vaccine formulations. [PDF]

Front Immunol
Coria LM, Pueblas Castro C, Bruno L, Nakaya HI, Pasquevich KA, Cassataro J.   +5 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Structure-Based Design of Covalent SARS-CoV‑2 Main Protease Inhibitors Targeting the Nirmatrelvir-Resistant E166 Mutants. [PDF]

JACS Au
Cai Z, Kohaal N, Georgiou K, Liang X, Chi X, Tan H, Tan B, Li K, Fan G, Lambrinidis G, Kolocouris A, Deng X, Chen Y, Wang J.   +13 more
europepmc   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Design and synthesis of 1,3,4-oxadiazole-tethered <i>N</i>-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and <i>in silico</i> studies. [PDF]

RSC Adv
Al-Warhi T, Islam Mukim MS, Elsayed ZM, Omar YM, Elimam DM, Shaldam MA, El-Damasy AK, Elbadawi MM, Tawfik HO, Song DG, Eldehna WM.   +10 more
europepmc   +1 more source