Results 211 to 220 of about 440,726 (262)
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Pharmacoenhancement of Protease Inhibitors
American Journal of Therapeutics, 2006Toxicity, adherence problems, and virological failure may limit treatment by protease inhibitor-containing regimens at standard doses. Addition of low-dose ritonavir results in a high plasma concentration of coadministered protease inhibitor resulting in decreased pill burden, a reduction in the number of doses, fewer food and/or fluid restrictions ...
Bharat, Motwani, Walid, Khayr
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Protease inhibitors: A panacea?
Journal of Biochemical and Molecular Toxicology, 2010AbstractWith the increasing evidence of protease involvement in several diseases, novel strategies for drug development involve the use of protease inhibitors (PIs). The local balance between protease inhibitors and proteases is an important determinant of the occurrence and progression of a particular disease.
Soghra Khatun, Haq +4 more
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Protease inhibitor monotherapy
Current Opinion in Infectious Diseases, 2011The present review focuses on recent data about boosted protease inhibitor monotherapy for maintenance of HIV virological suppression.Until recently most of the trials of boosted protease inhibitor monotherapy have studied lopinavir/ritonavir monotherapy.
Ignacio, Pérez-Valero, Jose R, Arribas
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Inhibitors of Cysteine Proteases
Current Topics in Medicinal Chemistry, 2006The roles of cysteine proteases (CP) as protein degrading and protein processing enzymes both in physiological and pathological processes of mammals are well known. Furthermore, the key roles of CP;s in the life cycles of infectious agents like protozoa and viruses turn them into new important targets for anti-infective drugs.
Radim, Vicik +3 more
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Protease Inhibitors and Urolithiasis
Journal of Urology, 1997We discuss the specific urological abnormalities associated with protease inhibitor therapy.We report on a human immunodeficiency virus positive patient who was on protease inhibitor therapy and presented with renal colic.The stone passed spontaneously.
S E, Sutherland +3 more
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Overview of Protease Inhibitors
Journal of the American Pharmaceutical Association (1996), 1997To provide a basic review of the four currently available protease inhibitors: saquinavir, ritonavir, indinavir, and nelfinavir. Included are sections on surrogate markers of HIV disease and resistance to protease inhibitor therapy, as well as dosing information, pharmacokinetics, studies, adverse effects, and drug interaction potential.Conducted a ...
A, Pakyz, D, Israel
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Proteases, protease inhibitors and radiation carcinogenesis
International Journal of Radiation Biology, 2021The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
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Proteases and protease inhibitors in infectious diseases
Medicinal Research Reviews, 2017AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro +3 more
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Proteases and Protease Inhibitors in Tumor Progression
1997Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex ...
Y A, DeClerck +5 more
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New England Journal of Medicine, 1998
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
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Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
openaire +2 more sources