Results 341 to 350 of about 3,573,509 (380)
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Protease Inhibitors in the Homeless
JAMA: The Journal of the American Medical Association, 1997Homeless people are often thought not to adhere to therapy. Should we try to make protease inhibitors available to them? The new therapies for human immunodeficiency virus (HIV) infection are expensive, and their use may lead to the development of drug resistance.
David R. Bangsberg +3 more
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Biopolymers, 1981
AbstractThere is a general parallelism in the strategy followed in the design of hormonal peptide analogs and protease inhibitors. However, in the latter, one more dimension has been added with the development of mechanism‐based inhibitors, a dimension that is not yet available for hormonal peptides because of the lack of knowledge about receptor ...
Miguel A. Ondetti, D. W. Cushman
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AbstractThere is a general parallelism in the strategy followed in the design of hormonal peptide analogs and protease inhibitors. However, in the latter, one more dimension has been added with the development of mechanism‐based inhibitors, a dimension that is not yet available for hormonal peptides because of the lack of knowledge about receptor ...
Miguel A. Ondetti, D. W. Cushman
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Pharmacoenhancement of Protease Inhibitors
American Journal of Therapeutics, 2006Toxicity, adherence problems, and virological failure may limit treatment by protease inhibitor-containing regimens at standard doses. Addition of low-dose ritonavir results in a high plasma concentration of coadministered protease inhibitor resulting in decreased pill burden, a reduction in the number of doses, fewer food and/or fluid restrictions ...
Bharat Motwani, Walid Khayr
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Protease inhibitors: A panacea?
Journal of Biochemical and Molecular Toxicology, 2010AbstractWith the increasing evidence of protease involvement in several diseases, novel strategies for drug development involve the use of protease inhibitors (PIs). The local balance between protease inhibitors and proteases is an important determinant of the occurrence and progression of a particular disease.
Rizwan Hasan Khan +4 more
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Protease inhibitor monotherapy
Current Opinion in Infectious Diseases, 2011The present review focuses on recent data about boosted protease inhibitor monotherapy for maintenance of HIV virological suppression.Until recently most of the trials of boosted protease inhibitor monotherapy have studied lopinavir/ritonavir monotherapy.
Ignacio Pérez-Valero, Jose R. Arribas
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Inhibitors of Cysteine Proteases
Current Topics in Medicinal Chemistry, 2006The roles of cysteine proteases (CP) as protein degrading and protein processing enzymes both in physiological and pathological processes of mammals are well known. Furthermore, the key roles of CP;s in the life cycles of infectious agents like protozoa and viruses turn them into new important targets for anti-infective drugs.
Tanja Schirmeister +3 more
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Protease Inhibitors and Urolithiasis
Journal of Urology, 1997We discuss the specific urological abnormalities associated with protease inhibitor therapy.We report on a human immunodeficiency virus positive patient who was on protease inhibitor therapy and presented with renal colic.The stone passed spontaneously.
Suzette E. Sutherland +3 more
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Overview of Protease Inhibitors
Journal of the American Pharmaceutical Association (1996), 1997To provide a basic review of the four currently available protease inhibitors: saquinavir, ritonavir, indinavir, and nelfinavir. Included are sections on surrogate markers of HIV disease and resistance to protease inhibitor therapy, as well as dosing information, pharmacokinetics, studies, adverse effects, and drug interaction potential.Conducted a ...
Amy L. Pakyz, Debra S. Israel
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Proteases, protease inhibitors and radiation carcinogenesis
International Journal of Radiation Biology, 2021The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
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ChemInform Abstract: Cysteine Proteases and Their Inhibitors
ChemInform, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Otto, Hans-Hartwig, Schirmeister, Tanja
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