Results 351 to 360 of about 3,573,509 (380)
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New England Journal of Medicine, 1998
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
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Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
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Seed proteases and protease inhibitors
Economic Botany, 1970This review, which unavoidably has to be of a highly selective nature, covers the literature through December, 1967, and is concerned with two classes of proteins which are involved in the metabolism of seeds: proteases and protease inhibitors. During germination, proteases degrade protein reserves of seeds with an attendant release of peptides, free ...
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Proteases and Protease Inhibitors in Tumor Progression
1997Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex ...
Ralph A. Reisfeld +5 more
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Protease Inhibitors in Plants: Genes for Improving Defenses Against Insects and Pathogens
, 1990For several decades researchers have been studying the biosynthesis and regulation in plants of specific chemicals associated with defense against pests and pathogens.
C. Ryan
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Proteases and protease inhibitors in cancer
Acta Histochemica, 1998The second conference on 'Proteases and protease inhibitors in cancer' was organized by the American Association for Cancer Research (AACR) and Acta Pathologica Microbiologica et Immunologica Scandinavica (APMIS). To understand the role of proteinases and to develop relevant synthetic inhibitors to stop or slow the progression of cancer, an integrated ...
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Protease inhibitors and erectile dysfunction
AIDS, 2001Increasing numbers of HIV-positive men receiving protease inhibitors (PI) complain of erectile dysfunction (ED). Through the analysis of 334 HIV-1-infected male outpatients, this study shows homosexuality, CD4 cell count, viral load, and indinavir treatment to be independent variables predictive of ED. Furthermore, a neuropathy of the sacral region was
S. Sollima +9 more
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Periplasmic Proteases and Protease Inhibitors
2014In general, proteases are involved in diverse functions; the most notable include digestive, protective, and regulatory processes. Digestive proteases are involved in protein degradation for nutritional purposes. About 35% of all entries in the MEROPS database are classified as serine proteases.
Kucz Nicolette +2 more
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Proteases and their inhibitors: today and tomorrow
Biochimie, 1991A major incentive in inhibitor research is that control of limited proteolysis constitutes a valuable pharmacological tool. Protease inhibitors have proved to be successful in influencing pathogenesis in many experimental models but a breakthrough to use in human therapy has mainly been restricted to aprotinin and angiotensin converting enzyme (ACE ...
Scharpe, Simon +5 more
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Lung Proteases and Protease Inhibitors
1977Homogenates of guinea pig lung show significant protease activity at pH values from 2.2 to 9.9. Perfusion results in increased activity in both acid and alkaline ranges. Protease activity can be extracted by repeated homogenization and sonication of the pellet.
George Kalnitsky, Jeffrey Ihnen
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Heterocyclic HIV-Protease Inhibitors
Current Medicinal Chemistry, 2013In the panorama of HIV protease inhibitors (HIV PIs), many efforts have been devoted to the development of new compounds with reduced peptidic nature in order to improve pharmacokinetics and pharmacodynamics features. The introduction of cyclic scaffolds in the design of new chemical entities reduces flexibility and affords more rigid inhibitors ...
CALUGI, CHIARA +2 more
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