Results 111 to 120 of about 204,426 (234)

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

The emerging role of ubiquitin-proteasome system dysfunction in the pathogenesis of perioperative neurocognitive disorders: a narrative review. [PDF]

Front Behav Neurosci
Ma M, Yang J, Yang Y, Li L.
europepmc   +1 more source

Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N -glycanase, with the proteasome

, 2005
Guangtao Li, Xiaoke Zhou, Gang Zhao, Hermann Schindelin, William J. Lennarz   +4 more
openalex   +2 more sources

Corrigendum: Elucidation of the Signatures of Proteasome-Catalysed Peptide Splicing

, 2021
Wayne Paes, German Leonov, Thomas Partridge, Annalisa Nicastri, Nicola Ternette, Persephone Borrow   +5 more
openalex   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Degradation of C-terminal Truncated αA-crystallins by the Ubiquitin–Proteasome Pathway

, 2007
Xinyu Zhang, Edward J. Dudek, Bing-Fen Liu, Linlin Ding, Alexandre F. Fernandes, Jack J.‐N. Liang, Joseph Horwitz, Allen Taylor, Fu Shang   +8 more
openalex   +2 more sources

Stabilization of p53 by Adenovirus E1A Occurs through Its Amino-terminal Region by Modification of the Ubiquitin-Proteasome Pathway [PDF]

, 1998
Takuma Nakajima, Kenichi Morita, Haruki Tsunoda, Shinobu Imajoh‐Ohmi, Hirofumi Tanaka, Hideyo Yasuda, Kinichiro Oda   +6 more
openalex   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Mitofusin MFN2 acts as a molecular sensor preventing protein aggregation and mitophagy, with a protective effect against apoptosis in Charcot-Marie-Tooth type 2A disease. [PDF]

Autophagy Rep
Joaquim M, Dohrn MF, Chevrollier A, Escobar-Henriques M.   +3 more
europepmc   +1 more source

Figure S1 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity

Priyanka S. Rana, James J. Ignatz-Hoover, Byung‐Gyu Kim, Ehsan Malek, Yuriy Federov, Drew Adams, Timothy A. Chan, James J. Driscoll   +7 more
openalex   +1 more source