Results 111 to 120 of about 411,261 (379)

Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: Implications for oxidative stress and insolubility of newly synthesized proteins [PDF]

, 2010
Maintaining protein homeostasis is vital to cell viability, with numerous studies demonstrating a role for proteasome inhibition occurring during the aging of a variety of tissues and, presumably, contributing to the disruption of cellular homeostasis ...
Dasuri, Kalavathi, Di Blasio, Alessia, Ebenezer, Philip J., Fernandez Kim, Sun Ok, Gavilán, Elena, Keller, Jeffrey N., Uranga, Romina Maria, Zhang, Le   +7 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Localized and Systemic Inflammatory Mediators in a Murine Acute Mastitis Model

Journal of Inflammation Research, 2021
Miyuki Takashima,1,2 Christian Lalonde,1 Laura Ashley Olszanski,1 Feng-Qi Zhao1 1Department of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, 05405, USA; 2Wakunaga Pharmaceutical Co. Ltd, Osaka, 532-0003, JapanCorrespondence: Feng-
Takashima M, Lalonde C, Olszanski LA, Zhao FQ   +3 more
doaj  

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Cell Reports, 2017
Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis
Christopher M. Webster, Elizabeth C. Pino, Christopher E. Carr, Lianfeng Wu, Ben Zhou, Lucydalila Cedillo, Michael C. Kacergis, Sean P. Curran, Alexander A. Soukas   +8 more
doaj   +1 more source

Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders.

Journal of Medicinal Chemistry, 2019
Proteasomes are multienzyme complexes that maintain protein homeostasis (proteostasis) and important cellular functions through the degradation of misfolded, redundant, and damaged proteins.
Evert Njomen, J. Tepe
semanticscholar   +1 more source

Towards quantitative prediction of proteasomal digestion patterns of proteins

, 2008
We discuss the problem of proteasomal degradation of proteins. Though proteasomes are important for all aspects of the cellular metabolism, some details of the physical mechanism of the process remain unknown.
Alexey Zaikin, Denis S Goldobin, Goldobin D S Mishto M Textoris-Taube K Kloetzel P M Zaikin A, Holzhütter H G, Witt S, Zaikin A   +5 more
core   +1 more source

Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]

, 2014
The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John, Boyd, Marie, Hutchison, Sharon, Mairs, Robert, Rae, Colin, Tesson, Mathias   +5 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms

Frontiers in Molecular Biosciences, 2019
Intracellular protein synthesis, folding, and degradation are tightly controlled processes to ensure proper protein homeostasis. The proteasome is responsible for the degradation of the majority of intracellular proteins, which are often targeted for ...
Suzan Kors, Karlijne W Geijtenbeek, E. Reits, Sabine Schipper-Krom   +3 more
semanticscholar   +1 more source

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. [PDF]

, 2020
Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown.
Chua, Bernadette A, Dillingham, Christopher H, Hatters, Danny M, Hidalgo San Jose, Lorena, Hong, Yuning, Kruta, Miriama, Signer, Robert AJ, Sunshine, Mary Jean   +7 more
core   +1 more source